Studies on Tertiary Amine Oxides. XL. Reactions of Aromatic N-Oxides with Oxindoles in the Presence of Acylating Agents
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概要
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1-Methyloxindole (II) reacted as an active methylene compound with acyl-adducts of quinoline 1-oxides (I, IX and VIII), forming 1-methyl-3-(2- or 4-quinolyl)oxindoles (III, XV or XI). The reaction with I in the presence of acetic anhydride or benzoyl chloride further proceeded and gave bis-quinolyl compound (IV) besides mono-quinolyl one (III). The order of effectiveness of acylating agents was acetic anhydride>benzoyl chloride>tosyl chloride. Pyridine 1-oxide (XVII) itself was also able to react with II in hot acetic anhydride to give four kinds of products, 2-pyridyl- (XX), bis-2-pyridyl- (XIX), 4-pyridyl-product (XXI) and acetate of XXI (XVIII). The reaction of oxindole (XXVI) with I progressed similarly and 3-(2-quinolyl)-oxindole (XXVII) was obtained.
- 公益社団法人日本薬学会の論文
- 1970-09-25
著者
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熊懐 稜丸
Faculty of Pharmaceutical Sciences, Setsunan University
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浜名 政和
Faculty of Pharmaceutical Sciences, Kyushu University
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熊懐 稜丸
Faculty Of Pharmaceutical Sciences Setsunan University
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熊懐 稜丸
Faculty Of Pharmaceutical Sciences Kyushu University:(present Address)tokyo College Of Pharmacy Kash
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浜名 政和
Faculty Of Pharmaceutical Sciences Kyushu University
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