Studies on Tertiary Amine Oxides. XXIV. Reactions of Aromatic N-Oxides with Enamines of Cyclohexanone in the Presence of Acylating Agents (1)
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概要
- 論文の詳細を見る
Quinoline 1-oxide racted smoothly with cyclohexanone enamines in the presence of acylating agent, producing 2-(2-quinolyl) cyclohexanone as a major product in a good yield after treatment of the raction mixture with hydrochloric acid. The effectiveness of acylating agents was as follows : benzoyl chloride>tosyl chloride>acetic anhydride〜acetyl chloride. The sequence of the reactivity of enamines was morpholine>piperidine->pyrrolidine-enamine. The reaction of pyridine 1-oxide and isoquinoline 2-oxide similarly proceeded in good yields, 2-(2-pyridyl)- and 2-(1-isoquinoly)-cyclohexanone being obtained, respectively. The structural elucidation of the products was effected by chemical methods and the examinations of their infrared and ultraviolet spectra.
- 公益社団法人日本薬学会の論文
- 1965-08-25
著者
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野田 浩司
産業医科大学薬剤部
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野田 浩司
Faculty of Pharmaceutical Sciences, Kyushu University
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浜名 政和
Faculty Of Pharmaceutical Sciences Kyushu University
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