Studies on Tertiary Amine Oxides. LVII. Re-examination of the Reaction of Quinoline 1-Oxide with Acetic Anhydride, and the Related Reactions

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概要

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• Detailed examination of the reaction of quinoline 1-oxide (1) with methacrylonitrile in the presence of acetic anhydride and the re-examination of the reaction of 1 with acetic anhydride have revealed that there is another reaction sequence leading to polyquinolylmethanes, [tri-(2-quinolyl) methane (5), N-(2-quinolyl)-2-(2-quinolylmethylene)-1,2-dihydroquinoline (11) and N-(2-quinolyl)-2-[di-(2-quinolyl) methylene]-1,2-dihydroquinoline (6)], besides the formation of carbostyril in the latter reaction. Reactions of 1 with acetic anhydride in the presence of quinaldine, di-(2-quinolyl)-methane (9), cyanoacetic acid, malonic acid and phenylacetic acid were also examined in connection with the exploration of the mechanism of the above reaction, and the possible mechanism has been proposed.

• 公益社団法人日本薬学会の論文
• 1976-10-25

著者

• 口野 嘉幸

  Faculty Of Pharmaceutical Sciences Kyushu University:(present Address)biology Division National Canc

• 舟越 和久

  Faculty of Pharmaceutical Sciences, Kyushu University

• 舟越 和久

  Faculty Of Pharmaceutical Sciences Kyushu University

• 執行 洋陸

  Faculty of Pharmaceutical Sciences, Kyushu University

• 園田 裕常

  Faculty of Pharmaceutical Sciences, Kyushu University

• 浜名 政和

  Faculty of Pharmaceutical Sciences, Kyushu University

• 執行 洋陸

  Tokyo Research Laboratories, Kowa Co., Ltd.,

• 浜名 政和

  Faculty Of Pharmaceutical Sciences Kyushu University

• 執行 洋陸

  Tokyo Research Laboratories Kowa Co. Ltd.

• 園田 裕常

  Faculty Of Pharmaceutical Sciences Kyushu University 62:(present Address):sato Pharm. Co.

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