Reaction of Tryptamine and Aniline with δ-Valerolactone and Its Dehydro Derivatives. A New Synthesis of 1,2,3,4,6,7,12,12b-Octahydroindolo [2,3-α] quinolizine
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概要
- 論文の詳細を見る
The reaction of tryptamine with δ-valerolactone in tetralin gave δ-hydroxyamide (3) as the main product and the lactam (4) as the minor product. However, the reaction of 5,6-dihydro-2-pyrone with tryptamine or aniline afforded a mixture of the corresponding αβ- and βγ-unsaturated lactams, whereas, 2-pyrone did not react with either tryptamine or aniline to give the corresponding pyridone. Cyclization of 3 or 4 by Bischler-Napieralski reaction and followed NaBH_4 reduction provided a convement synthesis of 1,2,3,4,6,7,12,12b-octahydroindolo [2,3-α] quinolizine (23).
- 公益社団法人日本薬学会の論文
- 1975-02-25
著者
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中川 昌子
Faculty of Pharmaceutical Sciences, Chiba University
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中川 昌子
千葉大薬
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日野 亨
千葉大 薬
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中川 昌子
Faculty Of Pharmaceutical Sciences Hokkaido University
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舟越 和久
Faculty of Pharmaceutical Sciences, Kyushu University
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中川 昌子
千葉大 薬
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舟越 和久
Faculty Of Pharmaceutical Sciences Kyushu University
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殿塚 雅克
Faculty Of Pharmaceutical Sciences Chiba University
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