Studies on the Bischler-Napieralski Reaction with Unsaturated Lactams. Syntheses of 5,6,9,10,11,12-Hexahydro-2,3-dimethoxybenzo [4,5-a]-benzo [f] quinolizinium and Dihydrosempervirine Salts

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概要

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• The Bischler-Napieralski cyclizations of 2-(3,4-dimethoxyphenethyl) hexahydro-Δ^<4,5>-3 (2H)-isoquinolone (V) and a mixture of V and the Δ^<5,10>-isomer, yielded 1,2,3,4,4a, 5,7,8-octahydro-benzo [g] 10,11-dimethoxybenzo [4,5-a] pyridocolinium chloride (VI) and the corresponding isomeric mixture (XI), respectively, both of which were dehydrogenated to yield the same product, 1,2,3,4-tetrahydrobenzo [g] 10,11-dimethoxybenzo [4,5-a] pyridocolinium iodide (VII). Dihydrosempervirine (XVII) was easily synthesized in the similar manner.

• 社団法人日本薬学会の論文
• 1968-03-25

著者

• 中川 昌子

  Faculty of Pharmaceutical Sciences, Chiba University

• 中川 昌子

  Faculty Of Pharmaceutical Sciences Hokkaido University

• 伴 義雄

  Faculty of Pharmaceutical Sciences, School of Medicine, Hokkaido University

• 伴 義雄

  Faculty Of Pharmaceutical Sciences Hokkaido University

• 伴 義雄

  School Of Pharmaceutical Science Toho University

• 中田 忠

  Faculty Of Pharmaceutical Sciences Hokkaido University

関連論文

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