Reaction of 1-Phenethyl-2 (1H)-pyridones with Phosphoryl Chloride. Formation of 1-Phenethyl-2-chloropyridinium Salts.

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概要

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• It was proved that the reaction of each of 1-phenethyl-2 (1H)-pyridone, 1-(3,4-methyl-enedioxyphenethyl)-2 (1H)-pyridone, and 1-(3,4-dimethoxyphenethyl)-2 (1H)-pyridone with phophoryl chloride gave the corresponding 2-chloropyridinium salt and not the cyclized product in every case. On being treated with dilute aqueous sodium hydroxide solution at a room temperature, these 2-chloropyridinium salts yielded the corresponding pyridones, which had been described as the ring cleavage of benzo [a] quinolizinium salts induced with various basic reagents.

• 公益社団法人日本薬学会の論文
• 1959-07-20

著者

• 中川 昌子

  Faculty Of Pharmaceutical Sciences Hokkaido University

• 米光 宰

  Faculty of Pharmaceutical Sciences, Hokkaido University

• 伴 義雄

  Pharmaceutical Institute Medical Faculty University Of Tokyo

• 大石 武

  北大・薬:(現)理化学研究所

• 大石 武

  Pharmaceutical Institute, School of Medicine, University of Hokkaido

• 米光 宰

  Pharmaceutical Institute, School of Medicine, University of Hokkaido

• 中川 昌子

  Pharmaceutical Institute, School of Medicine, University of Hokkaido

• 横山 晋

  Pharmaceutical Institute, Medical School, University of Hokkaido

• 横山 晋

  Pharmaceutical Institute Medical School University Of Hokkaido

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