Highly Stereoselective Total Synthesis of Methynolide, the Aglycon of the 12-Membered Macrolide Antibiotic Methymycin. II. Kinetic Acetalization and Synthesis of the Seco-Acid(Organic,Chemical)

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概要

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• A highly stereoselective synthesis of the seco-acid (3) of methynolide (1), the aglycon of the 12-membered macrolide methymycin was carried out, starting from D-glucose via the Wittig-Horner coupling of the two segments i (4) (C-9-C-I3) and ii (5) (C-l-C-8), which were synthesized by the use of p-methoxybenzyl and p-methoxybenzylidene acetal protecting groups for hydroxy functions.

• 公益社団法人日本薬学会の論文
• 1987-06-25

著者

• 及川 裕二

  Faculty Of Pharmaceutical Sciences Hokkaido University

• 米光 宰

  Faculty of Pharmaceutical Sciences, Hokkaido University

• 及川 裕二

  北大薬

• 米光 宰

  北海道大学薬学部

• 米光 宰

  Faculty Of Pharmaceutical Sciences Hokkaido University

• 浜田 辰夫

  Faculty of Pharmaceutical Sciences, Hokkaido University

• 田中 達義

  Faculty of Pharmaceutical Sciences, Hokkaido University

• 浜田 辰夫

  北大薬

• 米光 宰

  北大 薬

• 田中 達義

  Faculty Of Pharmaceutical Sciences Hokkaido University

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