Alternative Syntheses of the C9-C15 and C1-C5 Segments of Erythronolide A via Regio- and Stereo-Selective Reductive Ring Opening of 2,3-Epoxy Alcohols

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概要

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• Improved syntheses are described of two segments required for the total synthesis of (9S)-9-dihydroerythronolide. A, i.e., (2S, 3R, 4S, 5R)-2,4-dimethyl-5-(4-methoxybenzyloxy)heptane-1,3,4-triol corresponding to the C9-C15 subunit and (2S, 3R, 4R)-5-benzyloxy-2,3-dimethylpentane-1,4-diol corresponding to the C1-C5 subunit, via regio- and stereo-selective reduction of 2,3-epoxy alcohols.

• 社団法人日本薬学会の論文
• 1989-05-25

著者

• 及川 裕二

  Faculty Of Pharmaceutical Sciences Hokkaido University

• 米光 宰

  岡山理大理

• 米光 宰

  Faculty of Pharmaceutical Sciences, Hokkaido University

• 及川 裕二

  北大薬

• 米光 宰

  Faculty Of Pharmaceutical Sciences Hokkaido University

• 西 孝夫

  Third Institute of New Drug Research Otsuka Pharmaceutical Co., Ltd.,

• 西 孝夫

  Third Institute Of New Drug Research Otsuka Pharmaceutical Co. Ltd.

• 利根 斉

  Faculty of Pharmaceutical Sciences, Hokkaido University

• 西 孝夫

  Faculty of Pharmaceutical Sciences, Hokkaido University

• 彦田 匡毅

  Faculty of Pharmaceutical Sciences, Hokkaido University

• 浜田 辰夫

  Faculty of Pharmaceutical Sciences, Hokkaido University

• 彦田 匡毅

  北大薬

• 浜田 辰夫

  北大薬

• Nishi Takao

  Third Institute Of New Drug Research Otsuka Pharmaceutical Co. Ltd.

• 利根 斉

  Faculty Of Pharmaceutical Sciences Hokkaido University

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