Highly Stereoselective Total Synthesis of Tylonolide, the Aglycon of the 16-Membered Macrolide Antibiotic Tylosin. I. Construction of the C-1-C-8 Chiral Centers(Organic,Chemical)
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概要
- 論文の詳細を見る
In order to synthesize tylonolide, the aglycon of the 16-membered macrolide antibiotic tylosin, a Prelog-Djerassi lactone-type compound (4) corresponding to the C-1-C-9 segment was synthesized from D-glucose. Benzyl-type protecting groups for hydroxy functions, such as benzyl, 4-methoxybenzyl, and 3,4-dimethoxybenzyl groups, as well as some cyclic and acyclic stereocontrolled reactions, such as hydroboration, catalytic hydrogenation, and Grignard reaction, were successfully employed.
- 公益社団法人日本薬学会の論文
- 1987-06-25
著者
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及川 裕二
Faculty Of Pharmaceutical Sciences Hokkaido University
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米光 宰
Faculty of Pharmaceutical Sciences, Hokkaido University
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及川 裕二
北大薬
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米光 宰
北海道大学薬学部
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米光 宰
Faculty Of Pharmaceutical Sciences Hokkaido University
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浜田 辰夫
Faculty of Pharmaceutical Sciences, Hokkaido University
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田中 達義
Faculty of Pharmaceutical Sciences, Hokkaido University
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浜田 辰夫
北大薬
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米光 宰
北大 薬
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田中 達義
Faculty Of Pharmaceutical Sciences Hokkaido University
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