Facile Total Synthesis of Carbonolides by Witting-Hoener Macro-Cyclization and Stereoselective Epoxidation
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概要
- 論文の詳細を見る
Sixteen-membered dienone type macrolide aglycons, carbonolide B (1), niddanolide (5), and platenolide W_1 (6), were synthesized highly stereoselectively from D-glucose via Yamaguchi's esterification of two fragments, 8 (C1-C10) and 9 (C11-C16), followed by Witting-Horner cyclization. Stereoselective epoxidation of the 16-membered dienones (34,35) gave epoxy-enone-type macrolide aglycons, carbonolide A (2) and EOP aglycon (7).
- 公益社団法人日本薬学会の論文
- 1991-01-25
著者
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中島 範行
Faculty of Pharmaceutical Sciences, Science University of Tokyo
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畠 忠
Analytical and Metabolic Research Laboratories, Sankyo Co., Ltd.,
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米光 宰
岡山理大理
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米光 宰
Faculty of Pharmaceutical Sciences, Hokkaido University
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中島 範行
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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米光 宰
Faculty Of Pharmaceutical Sciences Hokkaido University
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魚戸 浩一
Exploratory Research Laboratories I, Daiichi Pharmaceutical Co. Ltd.,
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畠 忠
Analytical And Metabolic Research Laboratories Sankyo Co. Ltd.
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魚戸 浩一
Faculty of Pharmaceutical Sciences, Hokkaido University
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