Reaction of 19-Hydroxysteroids with Diethylaminosulfur Trifluoride
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概要
- 論文の詳細を見る
Reaction of 19-hydroxycholest-4-en-3-one (1) with diethylaminosulfur trifluoride (DAST) in acetonitrile at reflux gave 10β-fluoro-5,1-seco-5,19-cyclocholest-4-en-3-one (2) in 60% yield. Analogous reaction of androstane derivatives afforded the corresponding bicyclo[4.4.1] compounds 6 and 8. Under milder reaction conditions, the diethylaminosulfnate 3 was secured in 20% yield from 1.
- 社団法人日本薬学会の論文
- 1991-12-25
著者
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畠 忠
Analytical and Metabolic Research Laboratories, Sankyo Co., Ltd.,
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森崎 益雄
Kyoritsu College of Pharmacy
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猪野 宣人
Kyoritsu College of Pharmacy
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OINUMA Hisako
Kyoritsu College of Pharmacy
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山門 理恵子
Kyoritsu College of Pharmacy
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古川 洋司
Analytical and Metabolic Research Laboratories, Sankyo Co., Ltd.,
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古川 洋司
Analytical And Metabolic Research Laboratories Sankyo Co. Ltd.
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畠 忠
Analytical And Metabolic Research Laboratories Sankyo Co. Ltd.
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