Synthesis and Determination of Stereochemistry of Four Diastereoisomers at the C-24 and C-25 Positions of 3α, 7α, 12α, 24-Tetrahydroxy-5β-cholestan-26-oic Acid
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概要
- 論文の詳細を見る
Four diastereoisomers at the C-24 and C-25 positions of 3α, 7α, 12α, 24-tetrahydroxy-5β-cholestan-26-oic acid (varanic acid) were synthesized in a stereochemically defined manner and also by a non-stereoselective route, followed by chromatographic separation. Their stereochemistry at the C-24 and C-25 positions was established on the basis of the known stereochemical course of the reactions employed for the synthesis, and ^1H and ^<13>C-nuclear magnetic resonance spectroscopic data of these isomers. It is concluded from the present work that the previous stereochemical assignment for the (24R, 25S) and (24R, 25R) isomers must be revised.
- 公益社団法人日本薬学会の論文
- 1988-01-25
著者
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池川 信夫
新潟薬科大学
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池川 信夫
Department Of Chemistry Tokyo Institute Of Technology
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森崎 益雄
共立薬大
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森崎 益雄
Kyoritsu College of Pharmacy
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藤本 善徳
Department of Chemistry, Tokyo Institute of Technology
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藤本 善徳
Department Of Chemistry Tokyo Institute Of Technology
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柿沼 勝己
Department of Chemistry, Tokyo Institute of Technology
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宮田 昌明
Department Of Chemistry Tokyo Institute Of Technology
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柿沼 勝己
Department Of Chemistry Tokyo Institute Of Technology
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木下 工
Department of Chemistry, Tokyo Institute of Technology
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ISMAIL SHAHNAZ
Department of Chemistry, Tokyo Institute of Technology
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Ismail Shahnaz
Department Of Chemistry Tokyo Institute Of Technology
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木下 工
Department Of Chemistry Tokyo Institute Of Technology
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