Non-stereoselective Conversion of the Four Diastereoisomers at the C-24 and C-25 Positions of 3α, 7α, 12α, 24-Tetrahydroxy-5β-cholestan-26-oic Acid into Cholic Acid
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概要
- 論文の詳細を見る
The four diastereoisomers at the C-24 and C-25 positions of the title compound (varanic acid) were incubated with rat liver mitochondrial fraction supplemented with adenosine triphosphate, coenzyme A, nicotinamide adenine dinucleotide, and MgCl_2. All of these isomers were converted into cholic acid. Thus, the stereochemical configuration at the C-24 and C-25 positions has no significant effect on the efficiency of side chain cleavage of the tetrahydroxy acid into cholic acid.
- 公益社団法人日本薬学会の論文
- 1988-01-25
著者
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佐藤 良博
共立薬科大学名誉
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園田 よし子
Kyoritsu College of Pharmacy
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佐藤 良博
Kyoritsu College of Pharmacy
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池川 信夫
新潟薬科大学
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池川 信夫
Department Of Chemistry Tokyo Institute Of Technology
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森崎 益雄
共立薬大
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森崎 益雄
Kyoritsu College of Pharmacy
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藤本 善徳
Department of Chemistry, Tokyo Institute of Technology
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大谷 いずみ
Department of Chemistry, Tokyo Institute of Technology
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藤本 善徳
Department Of Chemistry Tokyo Institute Of Technology
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柿沼 勝己
Department of Chemistry, Tokyo Institute of Technology
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柿沼 勝己
Department Of Chemistry Tokyo Institute Of Technology
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木下 工
Department of Chemistry, Tokyo Institute of Technology
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大谷 いずみ
Department Of Chemistry Tokyo Institute Of Technology
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木下 工
Department Of Chemistry Tokyo Institute Of Technology
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