Lanosterol 14α-Demethylase (Cytochrome P-450_<14DM>) : Modulation of Its Enzyme Activity by Cholesterol Feeding
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概要
- 論文の詳細を見る
Regulation of the activity of lanosterol 14α-demethylase (cytochrome P-450_<14DM>) by dietary cholesterol was studied in rats. In male rats fed a 3% cholesterol diet for 1 and 4 weeks, the activity of 24,25-dihydrolanosterol 14α-demethylase was decreased in the liver. The cytochrome P-450_<14DM> protein content detected by immunoblotting was also decreased by cholesterol feeding. These results demonstrate that dietary cholesterol acts as a repressive factor for lanosterol 14α-demethylase. Further, the activity was enhanced by preincubation with phosphatase of the enzyme solution from both the control and cholesterol fed rats at the same rate. This result suggests that regulation of the activity involves phosphorylation of this enzyme.
- 公益社団法人日本薬学会の論文
- 1995-07-15
著者
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佐藤 良博
共立薬科大学名誉
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園田 よし子
Kyoritsu College of Pharmacy
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佐藤 良博
Kyoritsu College of Pharmacy
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関川 善夫
Department Of Pharmaceutical Sciences National Institute Of Public Health
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佐藤 良博
共立薬大
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遠藤 雅之
Kyoritsu College Of Pharmacy
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天野 千稚
Kyoritsu College of Pharmacy
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福原 守雄
Department of Pharmaceutical Sciences, National Institute of Public Health
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福原 守雄
Department Of Pharmaceutical Sciences National Institute Of Public Health
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