Solanum Alkaloids as Inhibitors of Enzymatic Conversion of Dihydrolanosterol into Cholesterol(Biological,Chemical)

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概要

• 論文の詳細を見る

• The effects of several solanum steroidal alkaloids on cholesterol biosynthesis from 24,25-dihydrolanosterol by 10000×g supernatant fluid of rat liver were examined. Solacongestidine (I), solafloridine (II) and solasodine (III) (40μM each) exhibited considerable inhibitory effects (59, 51, 37% inhibition, respectively) on the synthesis of cholesterol from [24,25-^3H]-24,25-dihydrolanosterol (18μM). The biological importance of the inhibitory properties of the steroidal alkaloids is discussed.

• 社団法人日本薬学会の論文
• 1987-10-25

著者

• 佐藤 良博

  共立薬科大学名誉

• 草野 源次郎

  Osaka University Of Pharmaceutical Sciences

• 草野 源次郎

  Pharmaceutical Institute, Tohoku University

• 高橋 昭

  Faculty Of Pharmaceutical Sciences Tohoku University

• 高橋 昭

  Pharmaceutical Institute, Tohoku University

• 野副 重男

  Pharmaceutical Institute, Tohoku University

• 園田 よし子

  Kyoritsu College of Pharmacy

• 佐藤 良博

  Kyoritsu College of Pharmacy

• 野副 重男

  東北大薬

• 野副 重男

  Pharmaceutical Institute Tohoku University

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