INHIBITORY EFFECT OF BISBENZYLISOQUINOLINE ALKALOIDS ON THE QUICK DEATH OF MICE TREATED WITH BCG/LPS

スポンサーリンク

概要

• 論文の詳細を見る

• Three bisbenzylisoqinoline alkaloids, chondocurine (Chon), berbamine (Ber), and cycleanine (Cyc) were tested for their protective effect on the quick death of mice primed with bacillus Calmette Guerin (BCG) and elicited with lipopolysaccharide (LPS). Seven-consecutive treatments with Chon or Cyc at a dose of 10 mg/kg following BCG priming resulted in significant improvement in the survival rate. A single dose of Chon also protected the BCG/LPS-treated mice from death if it was given immediately after, not 4 h after, LPS eliciation. These data show that bisbenzylisoquinoline alkaloids can protect mice from the lethal toxicity induced by the BCG/LPS combination treatment by inhibiting the priming with BCG or the elicitatin with LPS.

• 社団法人日本薬学会の論文
• 1990-10-25

著者

• 近藤 嘉和

  Pharmaceutical Inst Institute, Tohoku University

• 野副 重男

  Pharmaceutical Institute, Tohoku University

• 野副 重男

  東北大薬

• 野副 重男

  Pharmaceutical Institute Tohoku University

• 北條 博史

  Pharmaceutical Institute Tohoku University

• 今井 芳宏

  Pharmaceutical Institute, Tohoku University

• 久保田 佳幸

  Pharmaceutical Institute, Tohoku University

• 近藤 嘉和

  Pharmaceutical Institute Tohoku University

• 近藤 嘉和

  東北大学薬学部

• 今井 芳宏

  Pharmaceutical Institute Tohoku University

• 久保田 佳幸

  Pharmaceutical Institute Tohoku University

関連論文

• 18 沖縄産海洋生物より単離した新規生物活性物質の構造(口頭発表の部)
• 46 Eudistoma種のホヤの生物活性物質(口頭発表の部)
• Studies on the Constituents of Cimicifuga spp. XIII. Structure of Cimicifugoside
• Revised Structures of Flavidulos, Constituents of Lactarius flavidulus IMAI, and the Structure of Flavidulol D
• Chirality of the 3-Hydroxy-3-methylglutaric Acid Moiety of Fasciculic Acid A, a Calmodulin Antagonist Isolated from Naematoloma fasciculare
• Russuphelins B, C, D, E and F, New Cytotoxic Substances from the Mushroom Russula subnigricans HONGO
• Revised Structure and Stereochemistry of Hypothemycin
• 5-Lipoxygenase Inhibitors Isolated from the Mushroom Boletopsis leucomelas (PERS.) FAYOD
• Russuphelin A, a New Cytotoxic Substane from the Mushroom Russula subnigricans HONGO
• Repandiol, a New Cytotoxic Diepoxide from the Mushrooms Hydnum repandum and H. repandum var. album
• Isolation of 1-β-D-Arabinofuranosylcytosine from the Mushroom Xerocomus nigromaculatus HONGO
• Fasciculic Acids A, B and C as Calmodulin Antagonists from the Mushroom Naematoloma fasciculare
• Studies on the Constituents of Polyporus dispansus and P. confluens
• The Constituents of Lactarius flavidulus IMAI
• Antifungal Properties of Solanum Alkaloids(Biological,Chemical)
• Solanum Alkaloids as Inhibitors of Enzymatic Conversion of Dihydrolanosterol into Cholesterol(Biological,Chemical)
• 93(P29) ドクゼリ(Cicuta virosa)の中枢毒性成分研究(ポスター発表の部)
• 52(P13) チャツムタケ属担子菌のポリイソプレンポリオール類の立体構造(ポスター発表の部)
• α-マンゴスチンの筋小胞体カルシウム輸送ATPaseの阻害作用
• (S)-CIS-2-AMINO-5-CHLORO-4-PENTENOIC ACID FROM THE FUNGUS AMANITA VERGINEOIDES
• Confluentic Acid and 2'-O-Methylperlatolic Acid, Monoamine Oxidase B Inhibitors in a Brazilian Plant, Himatanthus sucuuba
• Synthesis of erythro-L-β-Hydroxyglutamic Acid Hydrochloride from L-Malic Acid
• 55 ブラジル産植物Cnidoscolus phyllacanthusから単離した新規細胞毒性成分の構造(ポスター発表の部)
• 12 不斉合成素子としてのL-ピログルタミン酸エステルの有効利用 : (-)-バルジシニンおよびカルバペネム類の合成(口頭発表の部)
• Confluentic Acid and 2'-O-Methylperlatolic Acid, Monoamine Oxidase B Inhibitors in a Brazilian Plant, Himatanthus sucuuba
• Cyclobutyl Cation Rearrangements of 6-Protoilluden-8α-ol, 7-Protoilluden-6-ol and Related Compounds(Organic,Chemical)
• Epimerization of 6-Protoilluden-8-one at C-3 and the Relative Thermodynamic Stabilities of Stereoisomeric 6-Protoilluden-8-ones
• Synthesis of 8-Hydroxy-6-protoilludene, a Probable Biosynthetic Intermediate of Humulene-Derived Sesquiterpenes Produced by Basidiomycetes
• SYNTHESIS OF dl-6-PROTOILLUDENE
• 38 オオワライタケの苦味成分,新ポリイソプレンポリオール,GymnopilinおよびGymnoprenol類の単離と構造
• オウバクより単離された γ-Hydroxybutenolide 誘導体と Limonoid の光酸化反応
• Long-range Effect of Halogen in the Nuclear Magnetic Resonance Spectra of Halosteroids
• (19) イネに含まれる抗白葉枯病菌物質について (I) (昭和51年度地域部会講演要旨(秋季関東部会))
• The Molecular and Crystal Structures of Two Derivatives of a Sesterterpene, Ophiobolin D
• Studies on Macrocyclic Lactone Antibiotics. III. Skeletal Structure of Azalomycin F_
• Studies on Macrocyclic Lactone Antibiotics. II. Partial Structures of Azalomycin F_
• Studies on Macrocyclic Lactone Antibiotics. I. Physicochemical Properties of Azalomycin F_
• 78 Azalomycin F_4の構造
• 5 稲いもち病菌の代謝する植物毒性物質
• (127) いもち病菌の生産するtenuazonic acidおよびその類縁化合物のいもち病防除効果について (昭和47年度 日本植物病理学会大会)
• INHIBITORY EFFECT OF BISBENZYLISOQUINOLINE ALKALOIDS ON THE QUICK DEATH OF MICE TREATED WITH BCG/LPS
• タンニン及び数種の関連化合物のラットのエタノ-ル胃損傷に対する効果
• イヌガンソクの成分研究 新フラバノンMatteucinおよびMethoxymatteucinの構造
• Studies on the Constituents of Chloranthus spp. III. Six Sesquiterpenes from Chloranthus japonicus
• Studies on Constituents of Iris Genus Plants. III. The Constituents of Iris florentina L. (1)
• Studies on Shikon. III. New Furylhydroquinone Derivatives, Shikonofurans A, B, C, D and E, from Lithospermum erythrorhizon SIEB. et ZUCC.
• Studies on the Constituents of Cimicifuga Species. XV.Two New Diglycosides from the Aerial Parts of Cimicifuga simplex WORMSK.
• Chloranthus属植物の成分研究.ヒトリシズカの成分研究補遺
• A New Acidic Amino Acid from a Basidiomycetes, Lactarius piperatus
• The Constituents of Gymnopilus spectabilis
• 川蜀七根の成分研究(第2報)スピロスタン系化合物の単離と構造研究
• 川蜀七根の成分研究(第1報)スピロスタン系サボゲニンの単離と構造研究
• Spasmolytic Substances from Cimicifuga dahurica MAXIM.
• Selective Chemical Alkylation of Nucleotides with Triethyloxonium Fluoroborate
• Protoberberine型アルカロイドの反応(第10報)Acetoneberberine-KMnO_4酸化生成物の構造 その2
• A Photoreductive Removal of the Toluene-p-sulfonyl Group
• 続随子の成分研究(第5報)種子油の成分について
• 続随子の成分研究(第4報)Ester L_3の構造について
• 93(P10) アクロナイシンおよび関連化合物の化学反応(ポスター発表の部)
• (2R), (1'R) and (2R), (1'S)-2-Amino-3-(1,2-dicarboxyethylthio)propanoic Acids from Amanita pantherina. Antagonists of N-Methyl-D-aspartic Acid(NMDA) Receptors
• 62 ドクササコおよびテングタケに含まれるグルタミン酸アゴニストおよびアンタゴニストに関する研究(ポスター発表の部)
• NITRIC OXIDE PRODUCTION IN MOUSE PERITONEAL MACROPHAGES ENHANCED WITH GLYCYRRHIZIN
• Iris属植物の成分研究(第6報)ニオイイリスIris florentina L.の根茎成分とシャガIris japonica THUNB.の花弁成分
• Absolute Stereochemistry of (-)-Preorixine and Related Compounds
• Proton Magnetic Resonance Study of Some 17-Substituted Steroids
• Synthesis of 2'-epi-Distichonic Acid A, an Iron-Chelating Amino Acid Derivative
• Application of the Infinite Dilution Shifts in Acid-Base System to Organic Chemistry. I.Relation between the Infinite Dilution Shifts of Monosubstituted Benzoic Acids in Pyridine and the Hammett δ Values
• Oxindoles(第5報)オキシインドール-スピロ二量体の選択的ソルボリシス
• Isolation of Ovulatory-Active Substances from Crops of Job's Tears (Coix lacryma-jobi L. var. ma-yuen STAPF.)
• ベルベリン熱分解物Berberrubineによる腫瘍細胞の増殖抑制
• Studies on the Constituents of Vitex rotundifolia L. fil.
• 数種のBerberinium塩の腸内常在菌に対する抗菌作用
• 薬理活性物質
• 生理活性物質の探索研究
• 天然物のもつ無限の可能性は変わらない(10年後の天然物化学は)
• 続随子の成分研究(第1報)Epoxylathyrolの単離と反応
• Synthesis of 5-Pyrazolylbarbituric Acid Derivatives
• Quinoline Alkaloids from Stems of Orixa japonica(Natural Medicine Note)
• ベルベリン熱分解物berberrubineによる腫瘍細胞の増殖抑制
• A New Diglyceride from Root-Barks of Morus alba L.
• The Structure of a New β-Carboline Alkaloid from Picrasma ailanthoides PLANCHON
• Reactions of Protoberberine-Type Alkaloids. IX. The Structure of a KMnO_4 Oxidation Product of Acetoneberberine. (I)
• The Structure of Cimifugin, a New Bitter Principle from Cimicifuga simplex WORMSK.
• 秦〓の成分研究
• 紫根の研究 : 硬紫根より得られた無色結晶
• 数種のBerberinium塩の腸内常在菌に対する抗菌作用

もっと見る 閉じる

スポンサーリンク