62 ドクササコおよびテングタケに含まれるグルタミン酸アゴニストおよびアンタゴニストに関する研究(ポスター発表の部)

概要

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An antagonist on NMDA sensitive glutamate receptors was isolated from a toadstool, Amanita pantherina and was demonstrated to be a diastereoisomeric mixture of 2-amino-3-(1,2-dicarboxyethylthio)propanoic acid (1). The mixture was resolved and the absolute configurations were determined as (2R), (1'R) and (2R), (1'S), respectively, by analysis of the optical properties. On the other hand, three analogs of the potent glutamate agonists, acromelic acids A (3) and B (4) were isolated from the poisonous mushroom, Clitocybe acromelalga.. The structures of these compounds, acromelic acids C, D and E were elucidated to be 5, 7 and 8, respectively, by comparison of the spectral data with those of 3 and 4. L-Stizolobic acid (9) and L-stizolobinic acid (10) were also isolated from C. acromelalga. The co-occurrence of these compounds and acromelic acids in the same mushroom strongly suggests that the pyridone moieties of acromelic acids are derived biosynthetically from L-DOPA.
天然有機化合物討論会の論文
1992-09-10