18 沖縄産海洋生物より単離した新規生物活性物質の構造(口頭発表の部)

概要

論文の詳細を見る
During our studies on bioactive metabolites from Okinawan marine organisms, we have isolated three bromopyrrole alkaloids, ageliferin (1), bromoageliferin (2), and dibromoageliferin (3), as potent actomyosin ATPase activators from the Okinawan marine sponge Agelas sp. Theonelladins A〜D (4〜7) are novel pyridine alkaloids with powerful Ca-releasing activity in sarcoplasmic reticulum from the Okinawan marine sponge Theonella swinhoei. From another Okinawan marine sponge Niphates sp. have been obtained niphatesines A〜D (8〜11), new antineoplastic pyridine alkaloids. Rigidin (12), a novel alkaloid with calmodulin antagonistic activity, has been isolated from the Okinawan marine tunicate Eudistoma cf. rigida. A new antiinflammatory diterpenoid, brianolide (13), has been obtained from the Okinawan gorgonian Briareum sp. The stereostructure of 13 was established by a single crystal X-ray analysis. Amphidinolide E (14), a novel antileukemic 19-membered macrolide has been isolated from the cultured symbiotic dinoflagellate Amphidinium sp. The structures of these bioactive metabolites have been elucidated from spectroscopic data including 2D NMR and chemical means.
天然有機化合物討論会の論文
1990-09-25