35 沖縄産のホヤ類および海綿動物より単離した抗腫瘍性化合物の構造(口頭発表の部)

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Recently, a variety of novel antineoplastic compounds have been isolated from Okinawan tunicates and sponges. Pseudodistomins A(1) and B(2), potent antineoplastic piperidine alkaloids with calmodulin antagonistic activity, have been isolated from the Okinawan tunicate Pseudodistoma kanoko. Cystodytins A(7), B(8) and C(9) are novel tetracyclic aromatic alkaloids with potent antineoplastic activity and powerful Ca-releasing activity in sarcoplasmic reticulum isolated from the Okinawan tunicate Cystodytes dellechiajei. From another Okinawan tunicate Didemnum sp. has been obtained a novel pentacyclic aromatic alkaloid, ascididemin(10), with potent antileukemic activity. Cystodytins and ascididemin might be originated from symbiotic microorganisms. Prianosins A(12), B(13), C(14) and D(15), novel sulfur-containing polycyclic alkaloids with potent antineoplastic activity have been isolated from the Okinawan marine sponge Prianos melanos. A novel lanosterol-derived metabolite, penasterol(18), with potent antileukemic activity has been obtained from the Okinawan marine sponge Penares sp. This is the first isolation of a marine sterol with a 14-carboxy group potentially important within the framework of sterol biosynthesis. Metachromins A(19) and B(20) are a novel antineoplastic sesquiterpenoid quinone and a chromenol isolated from the Okinawan marine sponge HilSpospongia cf. metachromia. The structures of these tunicate and sponge metabolites have been elucidated from spectroscopic data including 2D NMR and chemical means.
天然有機化合物討論会の論文
1988-09-26

35 沖縄産のホヤ類および海綿動物より単離した抗腫瘍性化合物の構造(口頭発表の部)

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