ALTOHYRTINS B AND C AND 5-DESACETYLALTOHYRTIN A, POTENT CYTOTOXIC MACROLIDE CONGENERS OF ALTOHYRTIN A, FROM THE OKINAWAN MARINE SPONGE HYRTIOS ALTUM
スポンサーリンク
概要
- 論文の詳細を見る
Following the characterization of altohyrtin A (1), altohyrtins B (2) and C (3) and 5-desacetylaltohyrtin A (4) have been isolated from the Okinawan marine sponge Hyrtios altum and their plane structures and parts of their relative configurations elucidated. Three congeneric macrolides (2,3,and 4) exhibit extremely potent cytotoxicities similar to those of 1 against KB cells with IC_<50> values of 0.02,0.4 and 0.3 ng/ml, respectively.
- 社団法人日本薬学会の論文
- 1993-05-15
著者
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北川 勲
Faculty of Pharmaceutical Sciences, Osaka University
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小林 資正
Faculty of Pharmaceutical Sciences, Osaka University
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佐々木 琢磨
金沢大学がん研究所化学療法部
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佐々木 琢磨
金沢大学がん研究所
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酒井 晴彦
大阪大学薬学部
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木原 典昭
大阪大学薬学部
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青木 俊二
Faculty of Pharmaceutical Sciences, Osaka University
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酒井 晴彦
Faculty of Pharmaceutical Sciences, Osaka University
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木原 典昭
Faculty of Pharmaceutical Sciences, Osaka University
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佐々木 琢磨
Cencer Research Institute, Kanazawa University
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佐々木 琢磨
金沢大 がん研
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小林 資正
阪大院薬
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北川 勲
Faculty Of Pharmaceutical Sciences Osaka University
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