Solubilization of Saponins of Bupleuri Radix with Ginseng Saponins : Effect of Malonyl-ginsenosides on Water Solubility of Saikosaponin-b
スポンサーリンク
概要
- 論文の詳細を見る
Saikosaponins, the active principles of Bupleuri Radix, are generally sparingly soluble in water. The solubilizing effect of Ginseng saponins on saikosaponin-b_1 (Sb_1) which is formed from saikosaponin-a (Sa) by mild acid treatment, was investigated. It was revealed that the significant increase of the water-solubility of Sb_1 with Ginseng saponin mixture was due mainly to malonyl-ginsenosides. Some solubilizing effect was also observed with ginsenoside-Ro (Ro). No solubilizing effect was found with the neutral dammarane saponins, while the effects of malonyl-ginsenosides and Ro were remarkably potentiated in the presence of these neutral dammarane saponins. The water-solubility of Sa was also increased in the presence of malonyl-ginsenosides under cooperation with the neutral dammarane saponins.
- 社団法人日本薬学会の論文
- 1991-05-25
著者
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笠井 良次
Institute of Pharmaceutical Sciences, Hiroshima University, School of Medicine
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田中 治
Institute of Pharmaceutical Sciences, Hiroshima University, School of Medicine
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北川 勲
Faculty of Pharmaceutical Sciences, Osaka University
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田中 治
広島大
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笠井 良次
広島大・医
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吉川 雅之
Faculty of Pharmaceutical Sciences, Osaka University
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北川 勲
Faculty Of Pharmaceutical Sciences Osaka University
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周 暁紅
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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田中 治
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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