Inhibitors of Cyclic AMP Phosphodiesterase in Panax ginseng C. A. MEYER and Panax japonicus C. A. MEYER

スポンサーリンク

概要

• 論文の詳細を見る

• Ginsenosides and chikusetsusaponins present in the roots of Panax ginseng C. A. MEYER and rhizomes of Panax japonicus C. A. MEYER were identified as inhibitors of cyclic AMP phosphodiesterase. The structure-activity relationships of 30 saponins, 2 prosapogenins and 3 sapogenins were studied. Saponins which have a 20 (S)-protopanaxadiol or oleanolic acid moiety as the sapogenin were generally more inhibitory towards cyclic AMP phosphodiesterase than saponins with a 20 (S)-protopanaxatriol moiety as the sapogenin. The effects of various ginsenosides on corticosterone secretion and cyclic AMP phosphodiesterase activity appeared to be parallel.

• 社団法人日本薬学会の論文
• 1984-04-25

著者

• 庄司 順三

  School of Pharmaceutical Sciences, Showa University

• 笠井 良次

  Institute of Pharmaceutical Sciences, Hiroshima University, School of Medicine

• 田中 治

  Institute of Pharmaceutical Sciences, Hiroshima University, School of Medicine

• 庄司 順三

  School Of Pharmaceutical Sciences Showa University

• 庄司 順三

  昭和大学薬学部

• 三川 潮

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 日合 奨

  富山医科薬科大学和漢薬研究所

• 笠井 良次

  広島大・医

• 大浦 彦吉

  Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University

• 大本 太一

  School of Pharmaceutical Sciences, Toho University

• 二階堂 保

  School of Pharmaceutical Sciences, Toho University

• 真田 修一

  School Of Pharmaceutical Sciences Showa University Hatanodai

• 三川 潮

  Faculty Of Pharmaceuical Sciences The University Of Tokyo

• 日合 奨

  Research Institute for Wakan-Yaku(Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceu

• 横山 弘臣

  Research Institute for WAKAN-YAKU, Toyama Medical and Pharmaceutical University

• 眞田 修一

  School of Pharmaceutical Sciences, Showa University

• 川島 祐次

  Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd.

• 田中 治

  Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine

• 川島 祐次

  Central Research Laboratories Yamanouchi Pharmaceutical Co. Ltd.

• 横山 弘臣

  Research Institute For Wakan-yaku Toyama Medical And Pharmaceutical University

• 庄司 順三

  昭和大学

関連論文

• Six New Triterpenoidal Glycosides Including Two New Sapogenols from Albizziac Cortex. V
• Saponins from Chinese Medicinal Plant, Hemsleya graciliflora (Cucurbitaceae)
• TUBEIMOSIDE I, A NEW CYCLIC BISDESMOSIDE FROM CHINESE CUCURBITACEOUS FOLX MEDICINE "TU BEI MU", A TUBER OF Bolbostemma paniculatum
• Saponins from Vietnamese Ginseng, Panax vietnamensis HA et GRUSHV. Collected in Central Vietnam. I
• ALKALOID FROM BARK OF ALBIZZIA MYRIOPHYLLA
• Saponins from Vietnamese Ginseng, Panax vietnamensis HA et GRUSHV. Collected in Central Vietnam. II
• Screening of Plant Constituents for Effect on Glucose Transport Activity in Ehrlich Ascites Tumour Cells
• Solubilization of Steviolbioside and Steviolmonoside with γ-Cyclodextrin and Its Application to Selective Syntheses of Better Sweet Glycosides from Stevioside and Rubusoside
• Phenolic Glycosides from Roots of Adenophora tetraphylla Collected in Heilongjiang, China
• Chemical Study on Haematoxylon campechianum : a Sweet Principle and New Dibenz[b, d]oxocin Derivatives
• Phenolic Glycosides from Nuo-Mi-Xang-Cao, a Chinese Acanthaceous Herb
• Minor Cucurbitane-Glycosides from Fruits of Siraitia grosvenori (Cucurbitaceae)
• Saponins from Leaves of Kalopanax pictus (THUNB.) NAKAI, Harigiri : Structures of Kalophanax-Saponins JLa and JLb
• Saponins from Bran of Quinoa, Chenopodium quinoa WILLD. II
• Saponins from Leaves of Kalopanax septemlobus (THUNB.) KOIDZ. : Structures of Kalopanax-saponins La, Lb and Lc
• Reticuloendothelial System-Activating Polysaccharides from Rhizomes of Panax japonicus. : I. Tochibanan-A and -B
• Alanysis of Saponins of Wild Panax gineseng
• Synthetic Study of the Ginseng Sapogenins : Preparation of Dammarenediol-II and Remote Oxidation of Dammaranediols with Photoexcited Nitrobenzene Derivatives
• Effect of Ginseng Saponins on Cholesterol Metabolism. II. Effect of Ginsenosides on Cholesterol Synthesis by Liver Slice
• Stimulation of Serum Protein Synthesis in Ginsenoside Treated Rat
• Effect of Ginseng Saponins on Nuclear Ribonucleic Acid (RNA) Metabolism. I. RNA Synthesis in Rats treated with Ginsenosides
• Effect of Ginseng Saponins on Cholesterol Metabolism. I. The Level and the Synthesis of Serum and Liver Cholesterol in Rats treated with Ginsenosides
• ACHYRANTHOSIDES C AND D, NOVEL GLUCURONIDE SAPONINS FROM ACHYRANTHES FAURIEI ROOT
• Studies on the Constituents of the Bark of Kalopanax pictus NAKAI
• Studies on the Constituents of Palmae Plants. III. : The Constituents of Chamaerops humilis L. and Trachycarpus wagnerianus BECC.
• Comparative Studies on the Constituents of Ophiopogonis Tuber and Its Congeners. IV. Studies on the Homoisoflavonoids of the Subterranean Part of Ophiopogon ohwii OKUYAMA and O. jaburan (KUNTH) LODD.
• Study on Saponins of Rhizomes of Panax pseudo-ginseng subsp. himalaicus Collected at Tzatogang and Pari-la, Bhutan-Himalaya
• Studies on the Constituents of Palmae Plants. II. The Constituents of Rhapis exelsa HENRY and R. humilis BL.
• Comparative Studies on the Constituents of Ophiopogonis Tuber and Its Congeners. III. Studies on the Constituents of the Subterranean Part of Ophiopogon ohwii OKUYAMA and O. jaburan (KUNTH) LODD.
• Studies on the Constituents of Palmae Plants. I. The Constituents of Trachycarpus fortunei (HOOK.) H. WENDL. (1)
• Comparative Studies on the Constituents of Ophiopogonis Tuber and Its Congeners. VI. : Studies on the Constituents of the Subterranean Part of Liriope spicata var. prolifera and L. muscari. (1)
• Comparative Studies on the Constituents of Ophiopogonis Tuber and Its Congeners. VIII. Studies on the Glycosides of the Subterranean Part of Ophiopogon japonicus KER-GAWLER cv. Nanus. (2)
• Comparative Studies on the Constituents of Ophiopogonis Tuber and Its Congeners. VII. Studies on the Homoisoflavonoids of the Subterranean Part of Ophiopogon japonicus KER-GAWLER cv. Nanus. (1)
• Potentiation of Nerve Growth Factor-Mediated Nerve Fiber Production in Organ Cultures of Chicken Embryonic Ganglia by Ginseng Saponins : Structure-Activity Relationship
• Solubilization of Saponins of Bupleuri Radix with Ginseng Saponins : Effect of Malonyl-ginsenosides on Water Solubility of Saikosaponin-b
• Studies on the Constituents of Panacis Japonici Rhizoma. V. The Structures of Chikusetsusaponin I, Ia, Ib, IVa and Glycoside P_1
• Studies on the Constituents of Himalayan Ginseng, Panax pseudoginseng. II. The Structures of the Saponins (2)
• Studies on the Saponins of Ginseng. II. Structures of Ginsenoside-Re, -Rf and -Rg_2
• Studies on the Saponins of Ginseng. I. Structures of Ginsenoside-Ro, -Rb_1,-Rb_2,-Rc and -Rd
• Studies on the Constituents of Himalayan Ginseng, Panax pseudoginseng. I. The Structures of the Saponins. (1)
• Studies on the Constituents of Panacis Japonici Rhizoma. IV. The Structure of Chikusetsusaponin V
• Studies on the Constituents of Panacis japonici Rhizoma. III. The Structure of Chikusetsusaponin. III.
• Inhibitors of Cyclic AMP Phosphodiesterase in Panax ginseng C. A. MEYER and Panax japonicus C. A. MEYER
• 3,4-Secolupane-Type Triterpene Glycosyl Esters from Leaves of Acanthopanax divaricatus SEEM(Pharmacognosy,Chemical)
• Comparative Studies on the Constituents of Ophiopogonis Tuber and Its Congeners. I. Studies of the Constituents of the Subterranean Part of Liriope platyphylla WANG et TANG. (1)
• Studies on the Constituents of Ophiopogonis Tuber. IV. On the Structures of Ophiopogonin A, B', C, C', and D'
• Saponins from Chinese Cucurbitaneous Plants : Solubilization of Saikosaponin-a with Hemslosides Ma2 and Ma3 and Structure of Hemsloside H_1 from Hemsleya chinensis
• Glycosides from Chinese Medicinal Plant, Hemsleya panacis-scandens, and Structure-Taste Relationship of Cucurbitane Glycosides
• Saponins from Leaves of Kalopanax pictum var. maximowiczii, a Korean Medicinal Plant
• 3,4-Seco-lupane Type Triterpene Glycosyl Esters from a Korean Medicinal Plant, Acanthopanax chiisanensis (Araliaceae)
• A NEW GLYCOSYL ESTER OF A 3,4-SECO-TRITERPENE FROM KOREAN MEDICINAL PLANT, ACANTHOPANAX CHIISANENSIS (ARALIACEAE)
• Studies on the Saponins of the Root of Platycodon grandiflorum A. DE CANDOLLE. I. Isolation and the Structure of Platycodin-D
• Studies on the Constituents of Aspidistra elatior BLUME. I. On the Steroids of the Underground Part
• Studies on the Saponins of Ginseng. IV. On the Structure and Enzymatic Hydrolysis of Ginsenoside-Ra_1
• Effect of Ginseng Saponins on Cholesterol Metabolism. III. Effect of Ginsenoside-Rb_1 on Cholesterol Synthesis in Rats fed on High-fat Diet
• Studies on the Saponins of Ginseng. III. Structures of Ginsenoside-Rb_3 and 20-Glucoginsenoside-Rf
• Mass Spectra of Trimethylsilyl Ethers of Dammarane-Type Ginseng-Sapogenins and Their Related Compounds
• Chemical Constituents of Pericarps of Rosa davurica PALL., a Traditional Chinese Medicine
• Comparative Studies on the Constituents of a Parasitic Plant and Its Host. III. On the Constituents of Boschniakia rossica FEDTSCH. et FLEROV.(2)(Pharmacognosy,Chemical)
• Inhibitory Effects of Cucurbitane Triterpenoids on Epstein-Barr Virus Activation and Two-Stage Carcinogenesis of Skin Tumors
• An Additional Sweet Dihydroflavonol Glycoside from Leaves of Engelhardtia chrysolepis, a Chinese Folk Medicine, Huang-qi
• Sweet and Bitter Diterpene-Glucosides from Leaves of Rubus suavissimus
• Constituents of Chinese Crude Drug "Wujiapi." I. Studies on the Aglycones of Steroidal Glycosides of Pei-wujiapi. (1)
• Studies on the Chemical Constituents of Chinese Drug "Wujiapi"
• Solubilizing Properties of Glycyrrhizin and Its Derivatives : Solubilization of Saikosaponin-a, the Saponin of Bupleuri Radix
• Spirostanol Glycosides from Peliosanthes sinica
• Saponins from Chinese Folk Medicine, "Liang Wang Cha," Leaves and Stems of Nothopanax delavayi, Araliaceae(Pharmacognosy,Chemical)
• Saponins of Zu-Tziseng, Rhizomes of Panax japonicus C.A. MEYER var. major (BURK.) C.Y. Wu et K.M. FENG, collected in Yunnan, China
• 19α-Hydroxyursane-Type Triterpene Glucosyl Esters from the Roots of Rubus suavissimus S. LEE
• Studies on Chemical Constituents of Antitumor Fraction from Periploca sepium. II. : Structures of New Pregnane Glycosides, Periplocosides A, B and C
• Studies on the Constituents of Ophiopogonis Tubers. VII. Synthetic Studies of Homoisoflavonoids. (3)
• Studies on the Constituents of Ophiopogonis Tuber. VI. Structures of Homoisoflavonoids. (2)
• Studies on the Constituents of Ophiopogonis Tuber. V. Isolation of a Novel Class of Homoisoflavonoids and Determination of Their Structures (1)
• Inhibitors of Cyclic Adenosine Monophosphate Phosphodiesterase in Polygala tenuifolid
• Saponins of Pericarps of Chinese Sapindus delavayi (Pyi-shiau-tzu), a Source of Natural Surfactants
• Chemical Evaluation of Bupleurum Species Collected in Yunnan, China
• Further Studies on Dammarane-Saponins of Sanchi-Ginseng
• ^C Nuclear Magnetic Resonance of Lupane-Type Triterpenes, Lupeol, Betulin and Betulinic Acid
• Chemical Studies on Sweet Diterpene-Glycosides of Stevia rebaudiana : Conversion of Stevioside into Rebaudioside-A
• Studies on the Constituents of Senegae Radix. III. The Structures of Senegin-III and -IV, Saponins from Polygala senega LINNE var. latifolia TORRY et GRAY.
• Studies on the Constituents of Senegae Radix. II. The Structure of Senegin-II, a Saponin from Polygala senega LINNE var. latifolia TORRY et GRAY
• On the Structure of Senegin-III of Senegae Radix
• On the Structure of Senegin-II of Senegae Radix
• Studies on the Constituents of Boschniakia rossica FEDTSCH. et FLEROV. I. Isolation and Structures of New Phenylpropanoid Glycosides, Rossicasides B, C and D
• Studies on the Constituents of Asparagi Radix. I. On the Structures of Furostanol Oligosides of Asparagus cochinchinensis (LOUREIO) MERRILL
• The Structures of Platycodin A and C, Monoacetylated Saponins of the Roots of Platycodon grandiflorum A. DC.
• Saponins of Red Ginseng
• Further Studies on Dammarane-Saponins of American Ginseng, Roots of Panax quinquefolium L.
• Ginsenoside-Ra_1 and Ginsenoside-Ra_2,New Dammarane-Saponins of Ginseng Roots
• Further Studies on Dammarane-Saponins of Ginseng Roots
• Saponins from Roots of Kalopanax septemlobus (THUNB.) KOIDZ., Ciqiu : Structures of Kalopanax-saponins C, D, E and F
• Studies on the Constituents of Ophiopogonis Tuber. III. On the Structure of Ophiopogonin D
• Studies on the Constituents of Ophiopogonis Tuber. II. On the Structure of Ophiopogonin B
• Studies on the Constituents of Palmae Plants. VI. Steroid Saponins and Flavonoids of Leaves of Phoenix canariensis hort. ex CHABAUD, P. humilis ROYLE var. hanceana BECC., P. dactylifera L., and Licuala spinosa WURMB.
• Studies on the Constituents of Palmae Plants. V. Steroid Sapnins and Flavonoids of Leaves of Phoenix rupicola T. ANDERSON, P. loureirii KUNTH, P. reclinate N. J. JACQUIN, and Arecastrum remanzoffianum BECCARI
• Studies on the Constituents of Palmae Plants. IV. : The Constituents of the Leaves of Sabal causiarum BECC.
• Studies on the Coloration Mechanism of Furostanol Derivatives with Ehrlich Reagent. II. On the Reaction of Furostanol Glycoside with Ehrlich Reagent
• Studies on the Coloration Mechanism of Furostanol Derivatives with Ehrlich Reagent. I. On the Reaction of 3,26-Dimethoxyfurost-5,20-diene with Ehrlich Reagent
• Studies on the Constituents of Aspidistra elatior BLUME. II. On the Steroidal Glycosides of the Leaves. (1)
• Decomposition of Usnic Acid. VII. Pyrolysis of Dihydrousnic Acid. (3). Isodihydrousnic Acid.

もっと見る 閉じる

スポンサーリンク