Effect of Ginseng Saponins on Nuclear Ribonucleic Acid (RNA) Metabolism. I. RNA Synthesis in Rats treated with Ginsenosides
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概要
- 論文の詳細を見る
The effect of ginsenosides purified from Ginseng (the roots of Panax ginseng C. A. MEYER) on nuclear ribonucleic acid (RNA) synthesis was investigated. Four hours after intraperitoneal injection of each of the ginsenosides (-Rb_1,-Rc, and -Rg_1) at a dose of 5 mg per 100 g body weight, incorporation of ^3H-orotic acid into nuclear RNA of rat liver was determined. The ginsenosides showed different activities : Rb_1 increased and Rc decreased the incorporation, and Rg_1 did not affect it. Furthermore, the effect of ginsenoside-Rb_1 and -Rc on RNA polymerase activity was investigated 3 hr after the intraperitoneal administration. Rb_1 enhanced and Rc repressed the enzyme activity, the results being consistent with those on the incorporation study. Both purified ginsenosides did not show any effect on RNA polymerase activity when added in vitro.
- 社団法人日本薬学会の論文
- 1976-10-25
著者
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庄司 順三
School of Pharmaceutical Sciences, Showa University
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庄司 順三
School Of Pharmaceutical Sciences Showa University
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真田 修一
School Of Pharmaceutical Sciences Showa University Hatanodai
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東 悳彦
Department Of Biochemistry School Of Pharmaceutical Sciences Showa University
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飯島 道子
School of Pharmaceutical Sciences, Showa University
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東 悳彦
School of Pharmaceutical Sciences, Showa University
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飯島 道子
School Of Pharmaceutical Sciences Showa University
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