Potentiation of Nerve Growth Factor-Mediated Nerve Fiber Production in Organ Cultures of Chicken Embryonic Ganglia by Ginseng Saponins : Structure-Activity Relationship

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概要

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• Potentiation of the nerve growth factor (NGF)-mediated nerve fiber production in organ cultures of chicken embryonic dorsal root ganglia (DRG) and lumbar sympathetic ganglia (SymG) by saponins isolated from Panax ginseng C. A. MAYER and Panax japonicum C. A. MAYER and related compounds was studied in order to elucidate the structure-activity relationship. Panax saponins and related compounds so far tested did not promote nerve fiber production, but some 20 (S)-protopanaxadiol glycoside having glucose units in their two sugar moieties potentiated the effect of NGF. Removal of glucose or introduction of a hydroxy group into the side chain of ginsenoside Rd reduced the activity. Little difference was observed in the potentiation of the NGF effect by the saponins in organ cultures of DRG and SymG.

• 社団法人日本薬学会の論文
• 1984-08-25

著者

• 上山 敬司

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 庄司 順三

  School of Pharmaceutical Sciences, Showa University

• 田中 治

  Institute of Pharmaceutical Sciences, Hiroshima University, School of Medicine

• 庄司 順三

  School Of Pharmaceutical Sciences Showa University

• 庄司 順三

  昭和大学薬学部

• 齋藤 洋

  Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo

• 柴田 承二

  Meiji College of Pharmacy

• 真田 修一

  School Of Pharmaceutical Sciences Showa University Hatanodai

• 柴田 承二

  Shibata Laboratory Of Natural Medicinal Materials C

• 柴田 承二

  明治薬大

• 竹本 裕美

  Institute For Medical And Dental Engineering Tokyo Medical And Dental University

• 齋藤 洋

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 堀尾 修平

  Faculty of Pharmaceutical Sciences, University of Tokushima

• 矢原 正治

  Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine

• 矢原 正治

  Faculty Of Pharmaceutical Sciences Kyushu University 62

• 田中 治

  Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine

• 堀尾 修平

  Faculty Of Pharmaceutical Sciences University Of Tokushima

• 庄司 順三

  昭和大学

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