Inhibitors of Cyclic Adenosine Monophosphate Phosphodiesterase in Polygala tenuifolid

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概要

• 論文の詳細を見る

• Cyclic adenosine monophosphate (AMP) phosphodiesterase inhibitors contained in Polygala tenuifolia WILLD. were identified as saponins and oleic acid. The concentrations of onjisaponins E, F and G required to give 50% inhibition (IC 50) were of the sameor der as that of papaverine. A kinetic study revealed that onjisaponin F acts non-competitively against cyclic AMP phosphodiesterase, like papaverine. Onjisaponin F exhibited a prolongation effect on hexobarbital sleeping time in mice.

• 公益社団法人日本薬学会の論文
• 1982-06-25

著者

• 庄司 順三

  School of Pharmaceutical Sciences, Showa University

• 庄司 順三

  School Of Pharmaceutical Sciences Showa University

• 三川 潮

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 斉藤 洋

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 三川 潮

  Faculty Of Pharmaceuical Sciences The University Of Tokyo

• 斉藤 洋

  Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo

• 佐久間 聖一

  School of Pharmaceutical Sciences, Showa University

• 二階堂 保

  Faculty of Pharmaceutical Sciences, Toho University

• 大本 太一

  Faculty of Pharmaceutical Sciences, Toho University

• 二階堂 保

  Faculty Of Pharmaceutical Sciences Toho University

• 佐久間 聖一

  School Of Pharmaceutical Sciences Showa University

• 庄司 順三

  昭和大学

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