Inhibition of Prostaglandin and Leukotriene Biosynthesis by Gingerols and Diarylheptanoids

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概要

• 論文の詳細を見る

• The rhizomes of Zingiber officinale (ginger) and Alpinia officinarum contain potent inhibitors against prostaglandin biosynthesizing enzyme (PG synthetase). Gingerols and diarylhepatanoids were identified as active compounds. Their possible mechanism of action which was deduced from the structures of active compounds indicated that the inhibitors would also be active against arachidonate 5-lipoxygenase, an enzyme of leukotriene (LT) biosynthesis, This was verified by testing their inhibitory effects on 5-lopoxygenase prepared from RBL-1 cells. A diarylheptanoid with catechol group was the most active compound against 5-lipoxygenase, while yakuchinone A was the most active against PG synthetase.

• 社団法人日本薬学会の論文
• 1992-02-25

著者

• 木内 文之

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 三川 潮

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 渋谷 雅明

  Faculty of Pharmaceutical Sciences, The University of Tokyo

• 三川 潮

  Faculty Of Pharmaceuical Sciences The University Of Tokyo

• 岩上 敏

  Faculty Of Pharmaceuical Sciences The University Of Tokyo

• 花岡 文雄

  Faculty Of Pharmaceuical Sciences The University Of Tokyo

• 木内 文之

  慶應義塾大学薬学部

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