THE BIOSYNTHESIS OF PATULIN : THE MECHANISM OF OXIDATIVE AROMATIC RING CLEAVAGE AND LOSS OF SIDE CHAIN PROTONS FROM AROMATIC INTERMEDIATES
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概要
- 論文の詳細を見る
Method to detect the incorporation of ^<18>O and ^2H by isotope shift in ^<13>C-NMR spectroscopy was applied to study the mechanism of patulin biosynthesis in Penicillium patulum NRRL 2159A. From the results of incorporation experiments with ^<18>O_2 and [1- ^<13>C, ^<18>O_2]-acetate, monooxygenase appeared to be involved in the ring cleavage of an aromatic intermediate. ^2H from [2-^<13>C, 2-^2H_3]-acetate was detected at C-5,but not at C-1,indicating that the side chain protons of the aromatic intermediate were lost in the course of patulin biosynthesis.
- 公益社団法人日本薬学会の論文
- 1983-01-25
著者
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三川 潮
Faculty of Pharmaceutical Sciences, University of Tokyo
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野口 博司
静岡県大薬
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野口 博司
静岡県立大学薬学部
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野口 博司
Faculty of Pharmaceutical Sciences, The University of Tokyo
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海老塚 豊
Faculty of Pharmaceutical Sciences, The University of Tokyo
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三川 潮
Faculty Of Pharmaceuical Sciences The University Of Tokyo
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瀬戸 治男
Institute of Applied Microbiology, University of Tokyo
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飯島 洋
Faculty Of Pharmaceutical Sciences University Of Tokyo
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飯島 洋
キリンビール(株)基盤技術研究所
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飯島 洋
日本大学
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野口 博司
Faculty Of Pharmaceutical Sciences The University Of Tokyo
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瀬戸 治男
Institute Of Applied Microbiology University Of Tokyo
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