BIOSYNTHESIS OF PATULIN; : IN VITRO CONVERSION OF GENTISYL ALCOHOL INTO PATULIN BY MICROSOMAL ENZYME(S) AND RETENTIOIN OF ONE OF THE CARBINOL PROTONS IN THIS REACTION

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概要

• 論文の詳細を見る

• The late stage of patulin biosynthesis was studied using cell-free preparation of Penicillium patulum NRRL 2159A. The substrate for the ring cleavage reaction was established to be gentisyl alcohol, which was converted into patulin by a microsomal enzyme(s). Incubation of [1'-^<14>C, ^3H_2]-gentisyl alcohol with the microsomal preparation revealed that one of the carbinol protons of this substrate is retained in patulin. This answers the long-standing question why the side chain protons of aromatic intermediates are not incorporated into patulin in feeding experiments.

• 公益社団法人日本薬学会の論文
• 1986-08-25

著者

• 三川 潮

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 海老塚 豊

  Faculty of Pharmaceutical Sciences, The University of Tokyo

• 三川 潮

  Faculty Of Pharmaceuical Sciences The University Of Tokyo

• 飯島 洋

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 飯島 洋

  キリンビール(株)基盤技術研究所

• 飯島 洋

  日本大学

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