Platelet Activating Factor (PAF) Antagonists Contained in Medicinal Plants : Lignans and Sesquiterpenes
スポンサーリンク
概要
- 論文の詳細を見る
Hot aqueous extracts of medicinal plants were tested for their inhibitory effect on the binding of platelet activating factor (PAF) to rabbit platelets. The extracts of Forsythia suspensa VAHL. (Oleaceae), Arctium lappa L. (Compositae) and Centipeda minima (L.) A. BRAUN et ASCHERS (Compositae) showed significant activities. Since the main constituents of F. suspensa and A. lappa are lignans, 30 lignans were tested for their inhibitory effects on PAF binding to platelets and 9 lignans were found active. Four sesquiterpenes were isolated as active compounds from C. minima. In particular 6-O-angeloylplenolin and 6-O-senecioylplenolin are the most potent and specific PAF antagonists found in this study.
- 社団法人日本薬学会の論文
- 1992-05-25
著者
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三川 潮
Faculty of Pharmaceutical Sciences, University of Tokyo
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海老塚 豊
Faculty of Pharmaceutical Sciences, The University of Tokyo
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三川 潮
富山医薬大薬
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三川 潮
Faculty Of Pharmaceuical Sciences The University Of Tokyo
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三川 潮
Faculty Of Pharmaceutical Sciences University Of Tokyo
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岩上 敏
Faculty Of Pharmaceuical Sciences The University Of Tokyo
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三川 潮
東大 薬
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呉 金濱
Faculty of Pharmaceutical Sciences, University of Tokyo
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呉 金濱
Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Sankawa U
International Research Center For Traditional Medicine
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Sankawa Ushio
(present Address)faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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Sankawa Ushio
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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