Inhibition of Phenylalanine Ammonia-lyase by Flavonoids
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概要
- 論文の詳細を見る
The inhibitory activity of flavonoids against L-phenylalanine ammonia-lyase [PAL ; EC 4.3.1.5] was systematically investigated. Twenty-three kinds of flavonoids were tested with three PAL preparations of different origins. Quercetin (8) was found to be the most active among the flavonoids tested and inhibited all three PAL preparations. Isoliquiritigenin (11), a biosynthetic intermediate of flavonoids, also showed relatively strong inhibition of PAL. However, the chalcone deactivated PAL in a time-dependent manner, and a model reaction with L-cysteine revealed that the chalcone formed an adduct with L-cysteine, indicating that PAL is deactivated by the Michael type addition of chalcone. The results obtained in this study suggest that the inhibitory activity of flavonoids against PAL does not occur by the mechanism of end product inhibition, as was suggested by Smith et al., but is merely a result of nonspecific deactivation of PAL.
- 社団法人日本薬学会の論文
- 1983-01-25
著者
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佐藤 俊次
Faculty Of Pharmaceutical Sciences University Of Tokyo
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三川 潮
Faculty of Pharmaceutical Sciences, University of Tokyo
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三川 潮
Faculty Of Pharmaceuical Sciences The University Of Tokyo
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