Inhibition of Adenosine 3', 5'-Cyclic Monophosphate Phosphodiesterase by Flavonoids. II
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概要
- 論文の詳細を見る
Thirty-eight flavones obtained from Scutellaria baicalensis and ninety six related flavones were tested for inhibitory activity against adenosine 3', 5'-cyclic monophosphate phosphodiesterase from beef heart. The most active inhibitor is 8-methoxy-5,7,2'-trihydroxyflavone from S. baicalensis. Its IC_<50> value is 0.6(× 10^<-5> M/l). The structure-activity relationships were investigated. a) O-Methylated flavones generally show lower inhibitory activity than the corresponding hydroxyflavones among the flavones having under four substituents. b) O-Methylated flavones generally show higher inhibitory activity than the corresponding hydroxyflavones in the flavones having over five substituents. (c) C-Glycosides are almost all poor inhibitors. (d) O-Glycosides are generally less potent than the corresponding flavones.
- 社団法人日本薬学会の論文
- 1988-02-25
著者
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三川 潮
Faculty of Pharmaceutical Sciences, University of Tokyo
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大本 太一
School of Pharmaceutical Sciences, Toho University
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富森 毅
School of Pharmacy, Hokuriku University
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二階堂 保
School of Pharmaceutical Sciences, Toho University
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三川 潮
Faculty Of Pharmaceuical Sciences The University Of Tokyo
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大本 太一
東邦大薬
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宮一 論起範
School of Pharmacy, Hokuriku University
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井本 吉隆
School of Pharmacy, Hokuriku University
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井本 吉隆
School Of Pharmacy Hokuriku University
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富森 毅
北陸大学薬学部
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富森 毅
School Of Pharmacy Hokuriku University
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宮一 諭起範
北陸大学薬学部
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