Inhibition of Adenosine 3', 5'-Cyclic Monophosphate Phosphodiesterase by Flavonoids from Licorice Roots and 4-Arylcoumarins

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概要

• 論文の詳細を見る

• Isoliquiritigenin, glabridin, licoarylcoumarin and licoricidin were identified as strong inhibitors of adenosine 3', 5'-cyclic monophosphate (cAMP) phosphodiesterase in waste materials which were obtained during the industrial extraction of glycyrrhizin from licorice roots. The structure-activity relationships of 12 flavonoids from licorice roots and 34 4-arylcoumarins were studied. In 4-arylcoumarins, 5,7-dihydroxy derivatives were generally highly inhibitory towards cAMP phosphodiesterase.

• 公益社団法人日本薬学会の論文
• 1991-04-25

著者

• 久家 隆司

  東邦大学薬学部

• 大本 太一

  School of Pharmaceutical Sciences, Toho University

• 二階堂 保

  School of Pharmaceutical Sciences, Toho University

• 二階堂 保

  東邦大学薬学部

• 大本 太一

  東邦大薬

• 草野 歩

  School Of Pharmaceutical Sciences Toho University

• BOTTA Bruno

  Centro Chimica dei Recettori del C.N.R., Universita Cattolica

• 斎藤 保

  Faculty Of Pharmaceutical Sciences Teikyo University

• Monache G.delle

  Centro Chimica Dei Recettori Del C.n.r. Universita Cattolica

• 久家 隆司

  School of Pharmaceutical Sciences, Toho University

• BOTTA Maurizio

  Centro Chimica dei Recettori del C.N.R., Universita Cattolica

• Botta Maurizio

  Centro Chimica Dei Recettori Del C.n.r. Universita Cattolica

• Botta Bruno

  Centro Chimica Dei Recettori Del C.n.r. Universita Cattolica

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