56 ユリ科ツルボ亜科植物の生理活性成分研究Cyclic AMP phosphodiesterase阻害活性を有する新規トリテルペン配糖体の構造(ポスター発表の部)

概要

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As part of a systematic study on the bioactive substances from Liliaceae plants, we have investigated six plants belonging to the subfamily Scilloideae in the Liliaceae. Scilla peruviana yielded three novel lanosterol trisaccharides, peruvianosides A (1), B (2) and C (3). Their structures were established by the concerted use of modern two-dimentional NMR techniques. Peruvianoside A (1)-C (3) are unique in structure having the rearranged lanostane skeleton. Futher, S. peruviana, Eucomis bicolor and Chionodoxa gigantea were shown to contain novel lanosterol penta- and hexasaccharides with the side-chain being modified to form the spiro-lactone group, scillasaponins A (4), B (5) and C (6), and norlanosterols (7-12). Scillasaponins may be the biological precursors of the norlanosterols. The structures of the new cholestane glycosides (13-22) from Ornithogalum saundersiae and O. thyrsoides, and steroidal saponins from Camassia cusickii (23 nad 24) are briefly discussed. The cholestane glycosides (13 - 15) have the migrated side-chain structures. The compounds isolated were evaluated for cyclic AMP phosphodiesterase inhibitory activity as the first screening test for finding new medicinal materials. Almost all the triterpene glycosides showed medium inhibitory activity, and the cholestane glycoside (18) and steroidal saponin (24) showed potent inhibitory activity.
天然有機化合物討論会の論文
1992-09-10