P-27 甘草(Glycyrrhiza glabra L.)抽出物のPPAR-γリガンド活性成分の探索と抗糖尿活性(ポスター発表の部)
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概要
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Peroxisome proliferators-activated receptor-γ (PPAR-γ), which belongs to the nuclear receptor superfamily, is expressed at high levels in the adipose tissue and functions as a master regulator of adipocyte differentiation. We have evaluated extracts of 70 spices and herbs for their PPAR-γ ligand-binding activity and found that the nonaqueous fractions of Glycyrrhiza uralensis F. and G glabra L. had higher activity than other materials tested. Previously, several phenolic compounds with PPAR-γ ligand-binding activity were isolated from the extract of G uralensis and glycyrin, one of the main PPAR-γ ligands of G uralensis, significantly decreased blood glucose levels of the genetically diabetic KK-A^y mice. In this study, we have isolated a total of 30 phenolic compounds, including 7 new ones (3, 4, 7, 14, 25, 27, 29), from the EtOH extract of G glabra using a PPAR-γ ligand binding activity-guided fractionation method. Among the isolated compounds, echinatin (1), 3,4,2',4'-tetrahydroxy-3',5-diprenylchalcone (4), (3R)-2',3',7-trihydroxy-4'-methoxyisoflavan (10), kanzonol X (11), glabridin (12), 2',4'-dihydroxy-5'-formyl-6",6"-dimethyl pyrano[2",3": 7,8] isoflavane (14), shinpterocarpin (20), licoagrocarpin (22), shinflavanone (23), (2R, 3R)-3,4',7-trihydroxy-3'-prenylflavone (25), and 4',7-dihydroxy-3',8-diprenylflavone (26) showed significantly PPAR-γ ligand-binding activity and were concluded to be responsible for the activity of the EtOH extract of G glabra. The enrich fraction of the hydrophobic phenolic compounds from G glabra, which was prepared by further extracting G glabra EtOH extract with medium-chain triglycerides, suppressed an increase in blood glucose level in obese diabetic KK-A^y mice. This result indicates that G glabra hydrophobic phenolics have hypoglycemic effect, possibly mediated via activation of PPAR-γ.
- 2007-08-24
著者
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本田 真一
(株)カネカ
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三巻 祥浩
東京薬大・薬・漢方資源応用
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黒田 明平
東京薬大・薬
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三巻 祥浩
東京薬大薬
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三巻 祥浩
School Of Pharmacy Tokyo Univ. Of Pharmacy And Life Sciences
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田中 穂積
(株)カネカ
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富永 雄仁
(株)カネカ
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横田 真一
(株)カネカ
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Kuroda M
Laboratory Of Medicinal Pharmacognosy Tokyo University Of Pharmacy And Life Sciences School Of Pharm
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黒田 明平
東京薬大薬
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Mimaki Y
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Mimaki Yoshihiro
Lab. Of Medicinal Pharmacognosy School Of Pharmacy Tokyo Univ. Of Pharmacy And Life Sciences
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Mimaki Yoshihiro
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Mimaki Yoshihiro
School Of Pharmacy Tokyo Univ. Of Pharmacy And Life Sciences
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Kuroda Minpei
Laboratory Of Medicinal Pharmacognosy Tokyo University Of Pharmacy And Life Science School Of Pharma
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三巻 祥浩
東京薬大・薬
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