Triterpene Glycosides from the Tubers of Anemone coronaria
スポンサーリンク
概要
- 論文の詳細を見る
Six new triterpene glycosides (1—6), together with 11 known ones (7—17), have been isolated from a glycoside-enriched fraction prepared from the tubers of Anemone coronaria L. (Ranunculaceae). On the basis of extensive spectroscopic analysis, including 2D NMR data, and the results of hydrolytic cleavage, the structures of 1—6 were determined to be 3β-[(O-β-D-glucopyranosyl-(1→4)-O-[α-L-rhamnopyranosyl-(1→2)]-α-L-arabinopyranosyl)oxy]-2β,23-dihydroxyolean-12-en-28-oic acid (1), 3β-[(O-β-D-glucopyranosyl-(1→3)-O-α-L-rhamnopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→4)]-α-L-arabinopyranosyl)oxy]-23-hydroxyolean-12-en-28-oic acid (2), 3β-[(O-β-D-glucopyranosyl-(1→4)-O-[α-L-rhamnopyranosyl-(1→2)]-α-L-arabinopyranosyl)oxy]-23-hydroxyolean-12-en-28-oic acid O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl ester (3), 3β-[(O-β-D-glucopyranosyl-(1→4)-O-[α-L-rhamnopyranosyl-(1→2)]-α-L-arabinopyranosyl)oxy]-2β,23-dihydroxyolean-12-en-28-oic acid O-α-L-rhamnopyranosyl-(1→4)-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl ester (4), 3β-[(O-β-D-glucopyranosyl-(1→4)-O-[α-L-rhamnopyranosyl-(1→2)]-α-L-arabinopyranosyl)oxy]-2β-hydroxyolean-12-en-28-oic acid O-α-L-rhamnopyranosyl-(1→4)-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl ester (5), and 3β-[(O-β-D-glucopyranosyl-(1→4)-O-[α-L-rhamnopyranosyl-(1→2)]-α-L-arabinopyranosyl)oxy]-23-hydroxyolean-18-en-28-oic acid O-α-L-rhamnopyranosyl-(1→4)-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl ester (6), respectively. Furthermore, the isolated compounds were evaluated for their cytotoxic activity against HSC-2 cells.
- 公益社団法人 日本薬学会の論文
著者
-
Sakagami Hiroshi
Department of Health and Nutrition Sciences,Tokyo Seiei College
-
Watanabe K
School Of Life Science Tokyo University Of Pharmacy And Life Science
-
三巻 祥浩
School Of Pharmacy Tokyo Univ. Of Pharmacy And Life Sciences
-
Matsuo Yukiko
Laboratory of Veterinary Pharmacology, Division of Veterinary Science, Osaka Prefecture University G
-
Matsuo Yukiko
School Of Pharmacy Tokyo Univ. Of Pharmacy And Life Sciences
-
MIMAKI Yoshihiro
Laboratory of Medicinal Plant Science, School of Pharmacy, Tokyo University of Pharmacy and Life Sci
-
Sakagami Hiroshi
Department Of Dental Pharmacology Meikai University School Of Dentistry
-
Mimaki Y
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
-
Mimaki Yoshihiro
Laboratory Of Medical Plant Science Tokyo University Of Pharmacy And Life Science
-
Watanabe Kazuki
Faculty of Pharmaceutical Sciences, Aomori University
-
Mimaki Yoshihiro
School Of Pharmacy Tokyo Univ. Of Pharmacy And Life Sciences
-
Matsuo Yukiko
Laboratory Of Medicinal Pharmacognosy School Of Pharmacy Tokyo University Of Pharmacy And Life Scien
-
Sakagami Hiroshi
Department Of Biochemical Pharmacology Tokyo Metropolitan Institute Of Gerontology
-
Watanabe Kazuki
Faculty Of Pharmaceutical Sciences Aomori University
-
Mimaki Yoshihiro
Laboratory of Medicinal Pharmacognosy, Tokyo University of Pharmacy and Life Sciences, School of Pharmacy
-
Matsuo Yukiko
Laboratory of Medicinal Pharmacognosy, Tokyo University of Pharmacy and Life Sciences, School of Pharmacy
関連論文
- Furostanol glycosides from the rhizomes of Helleborus orientalis
- Steroidal Glycosides from Furcraea foetida and Their Cytotoxic Activity
- Chemical Constituents of the Bulbs of Habranthus brachyandrus and Their Cytotoxic Activities
- Triterpene Glycosides from the Whole Plant of Anemone hupehensis var. japonica and Their Cytotoxic Activity
- 海馬スライスにおいてPKA依存的シグナル伝達を促進する nobiletin はAβ誘発性記憶障害を改善する
- 柑橘類成分F-1の記憶・学習障害改善作用とそのメカニズム
- 海馬スライスにおける陳皮成分 nobiletin のLTP誘導作用
- CREBを活性化するノビレチンはNMDA受容体遮断薬により誘発される記憶・学習障害を改善する
- Lewis Acid-Catalyzed Asymmetric Diels-Alder Reactions Using Chiral Sulfoxide Ligands : Chiral 2-(Arylsulfinylmethyl)-1,3-oxazoline Derivatives
- Cationic Copper(II)-Oxazoline-Sulfoxide catalysts: Application to Asymmetric Diels-Alder Reactions
- 56(P-23) Enterolobium contortisiliquumより単離された新規トリテルペン配糖体の構造とそれらのマクロファージに対する細胞毒性活性(ポスター発表の部)
- ヒガンバナ科アルカロイド, リコリン及びリコリシジノールによる炎症性サイトカイン, TNF-α産生の阻害
- 77(P-71) Securidaca inappendiculataより単離されたマクロファージ細胞死誘導活性物質の構造(ポスター発表の部)
- ヒメハギ科センヨクトウ (蝉翼藤) 由来サポニンのマクロファージに選択的な細胞死誘導作用 : 免疫・アレルギー (3)
- 神経栄養因子活性を有する天然生理活性物の探索とアルツハイマー病治療薬開発への応用
- ICRマウスの抗-DNPモノクローナルIgE抗体感作動物モデルにおけるノビレチンの皮膚炎および〓痒に対する効果
- 再録報文 Radical Scavenging Activity and Inhibition of Macrophage NO Production by Fukinolic Acid,a Main Phenolic Constituent in Japanese Butterbur(Petasites japonicus)
- Biological activity of a fruit vegetable, "Anastasia Green", aspecies of sweet pepper
- Cytotoxic Activity of 2-Aminomethylene-3(2H)-benzofuranones against Human Oral Tumor Cell Lines
- Cytotoxic Activity of Benzothiepins against HumanOral Tumor Cell Lines
- Cytotoxic Activity of 5-Benzoylimidazole and RelatedCompounds against Human Oral Tumor Cell Lines
- 89(P26) Galtonia candicansより単離されたコレスタン配糖体の構造とそれらの培養腫瘍細胞に対する増殖抑制活性(ポスター発表の部)
- P-12 ブラジル産伝承生薬Stryphnodendron fissuratum,Ateleia glaziovianaに含有される化学成分と細胞毒性活性(ポスター発表の部)
- 125(P-84) 和漢薬「蒟蒻薯(Tacca chantrieriの根茎)」の化学成分と細胞毒性活性(ポスター発表の部)
- Steroidal Saponins from the Underground Parts of Hosta longipes and Their Inhibitory Activity on Tumor Promoter-Induced Phospholipid Metabolism
- Structures of Steroidal Saponins from the Tubers of Brodiaea californica and Their Inhibitory Activity on Tumor Promoter-Induced Phospholipid Metabolism
- Inhibitory Effects of Steroidal Saponins on 12-O-Tetradecanoylphorbol-13-acetate (TPA)-Enhanced ^P-Incorporation into Phospholipids of HeLa Cells and Proliferation of Human Malignant Tumor Cells
- Lignans from Santalum album and Their Cytotoxic Activities
- Three New Cholestane Bisdesmosides from Nolina recurvata Stems and Their Inhibitory Activity on cAMP Phosphodiesterase and Na^+/K^+ ATPase
- Interleukin-19 Is a Negative Regulator of Innate Immunity and Critical for Colonic Protection
- P-27 甘草(Glycyrrhiza glabra L.)抽出物のPPAR-γリガンド活性成分の探索と抗糖尿活性(ポスター発表の部)
- 50(P-15) 甘草抽出物の抗糖尿病および抗内臓肥満活性とPPAR-γリガンド活性を指標とした活性成分の検索(ポスター発表の部)
- 機能性ハーブの生理活性に関する研究 Black Cohoshの抗ストレス作用について (第14回天然薬物の開発と応用シンポジウム 講演要旨集) -- (一般講演 機能性食品開発への新しいアプローチ)
- 63(P-20) Ornithogalum thyrsoidesより単離されたOSW-1類縁化合物の構造とそれらの腫瘍細胞に対する増殖抑制活性(ポスター発表の部)
- α-Trifluoromethylacyloins Induce Apoptosis in HumanTumor Cell Lines
- New Polyhydroxylated Steroidal Sapogenin and Saponin from the Leaves of Cestrum sendtenerianum
- Molecular Phylogenetic Relationships Between Prostanoid-Containing Okinawan Soft Coral (Clavularia viridis) and Nonprostanoid-Containing Clavularia Species Based on Ribosomal ITS Sequences
- Isolation of Peridinin-Related Norcarotenoids with Cell Growth-Inhibitory Activity from the Cultured Dinoflagellate of Symbiodinium sp., a Symbiont of the Okinawan Soft Coral Clavularia viridis, and Analysis of Fatty Acids of the Dinoflagellate
- P-19 Allium karatavienseおよびEranthis cilicicaより単離された新規高極性ステロイドならびにトリテルペン配糖体の化学構造に関する研究(ポスター発表の部)
- ユリ科クロユリ鱗茎の配糖体成分 (食品薬学シンポジウム講演要旨集)
- 高等植物からの新規医薬品シードの探索 (第16回 天然薬物の開発と応用シンポジウム講演要旨集) -- (シンポジウム3 医薬シーズ開発を志向した植物成分研究の新展開)
- 簡便な植物色素の分析法と〔東京薬科大学〕薬学部生薬系植物学実習での実践
- A Carbon-Centered Radical as a Reaction Species in the DNA Strand-Breakage by D-Glucosamine
- FORMATION OF TRICYCLIC HETEROCYCLES FROM THE CONDENSATION REACTION OF 1,2-DIAMINES WITH 1,2-DIKETONES
- A NOVEL 16,23-EPOXY-5β-CHOLESTANE GLYCOSIDE WITH POTENT INHIBITORY ACTIVITY ON PROLIFERATION OF HUMAN PERIPHERAL BLOOD LYMPHOCYTES FROM ORNITHOGALUM SAUNDERSIAE BULBS
- A NOVEL HEXAHYDRODIBENZOFURAN DERIVATIVE WITH POTENT INHIBITORY ACTIVITY ON MELANIN BIOSYNTHESIS OF CULTURED B-16 MELANOMA CELLS FROM LINDERA UMBELLATA BARK
- Convallasaponin A, a New 5β-Spirostanol Triglycoside from the Rhizomes of Convallaria majalis
- Four New Steroidal Saponins from the Rhizomes of Helleborus orientalis
- Norlanostane and Lanostane Glycosides from the Bulbs of Chionodoxa luciliae and Their Cytotoxic Activity
- Cycloartane Glycosides from the Rhizomes of Cimicifuga racemosa and Their Cytotoxic Activities
- Five New Triterpene Glycosides from Centella asiatica
- Steroidal Glycosides from the Bulbs of Camassia leichtlinii and Their Cytotoxic Activities
- Structures of Toxic Steroidal Saponins from Narthecium asiaticum MAXIM.
- Nobiletin, a Citrus Flavonoid That Improves Memory Impairment, Rescues Bulbectomy-Induced Cholinergic Neurodegeneration in Mice
- Polyphenols from Eriobotrya japonica and Their Cytotoxicity against Human Oral Tumor Cell Lines
- Triterpene Glycosides from the Stems of Akebia quinata
- Sesquiterpenoids and Flavonoids from the Aerial Parts of Tithonia diversifolia and Their Cytotoxic Activity
- Triterpenes and Triterpene Saponins from the Stems of Akebia trifoliata
- Cytotoxic Activities and Structure-Cytotoxic Relationships of Steroidal Saponins
- Cholestane Glycosides from the Bulbs of Galtonia candicans and Their Cytotoxicity
- Steroidal Saponins from the Bulbs of Allium karataviense
- Steroidal Saponins from the Bulbs of Allium ampeloprasum
- A New Concise Synthesis of Arcyriacyanin A and Its Unique Inhibitory Activity against a Panel of Human Cancer Cell Line
- A Synthesis of Arcyriacyanin A, an Unsymmetrically Substituted Indole Pigment of the Slime Mould by Palladium Catalyzed Cross-Coupling Reaction
- Triterpene Glycosides from the Tubers of Anemone coronaria
- New Steroidal Glycosides from Rhizomes of Clintonia udensis
- A Novel Polyoxygenated Spirostanol Trisdesmoside from the Rhizomes of Helleborus orientalis
- Diels-Alder Reaction of 1, 3-Butadiene Derivatives with 1-Methyl-2(1H)-quinolones Having an Electron-Withdrawing Group at the 4-Position
- Diels-Alder Cycloadditions of 2(1H)-Quinolones Having an Electron-Withdrawing Group at the 3-Position Acting as Dienophiles with Dienes
- Diels-Alder Reactions of Nitro-2(1H)-pyridones with 2, 3-Dimethyl-1, 3-butadiene
- Synthesis of Phenanthridones Using Diels-Alder Reactions of 4-Substituted 2(1H)-Quinolones Acting as Dienophiles
- Synthesis of Fluorine Analogs of Protoporphyrin Potentially Useful for Diagnosis and Therapy of Cancer(Part 3)Synthesis of(2,2-Difluorovinyl)trifluorovinyl- and(1-Chloro-2,2-difluorovinyl)-(2,2-difluorovinyl)deuteroporphyrin
- Synthesis of Fluorine Analogs of Protoporphyrin Potentially Useful for Diagnosis and Therapy of Cancer. IV.Synthesis of (Trifluorovinyl)vinyl-and (1-Chloro-2,2-difluorovinyl)vinyldeuteroporphyrins
- Azadirachta indica, a tropical medicinal plant with possible utility for the treatment of parasitoses
- A brief note on the Sannaimaruyama-Iseki Remains of the Jomon period in Aomori Prefecture with special comments on paleoparasitological aspects
- Taccasterosides A-C, Novel C_-Sterol Oligoglucosides from the Rhizomes of Tacca chantrieri(Communication to the Editor)
- Two New Steroidal Glycosides from Tacca chantrieri
- Four New 3,5-Cyclosteroidal Saponins from Dracaena surculosa
- Construction of the Curriculum and Lectures for the Subject, "History of Pharmacy" in Matsuyama University School of Pharmacy
- A Chronological Research on Parasitic Endemic Disease, "Katayama-disease" (schistosomiasis japonica) in Hiroshima Prefecture in the 20th Century : The 3rd Communication on the Historical Research on schistosomiasis japonica in Hiroshima Prefecture
- Spontaneous disappearance of a renal arteriovenous malformation
- HISTONE H1 DEPLETION WITH HUMAN CELLULAR AGING : BIOCHEMICAL AND CYTOCHEMICAL EVIDENCES (Histo- and Cytochemistry in Tissue Culture)
- 本学[東京薬科大学]薬学部における漢方薬物学実習の実施概要
- 蒟蒻薯(タシロイモ科植物Tacca chantrieriの根茎)の化学成分 (食品薬学シンポジウム講演要旨集)
- 天然素材からの新規機能性成分の探索 (シンポジウム:機能を持つ化粧品の有用性を支える技術)
- PPARγリガンド活性を指標としたハーブのメタボリックシンドローム予防・改善作用の解明 (特集 ハーブ療法のサイエンスとエビデンスの構築に向けて)
- ハーブのα-グルコシダーゼおよびキサンチンオキシダーゼ阻害活性によるメタボリックシンドローム予防・改善作用の解明 (特集 ハーブ療法のサイエンスとエビデンスの構築に向けて)
- タシロイモ科植物Tacca chantrieriの化学成分と細胞毒性活性 (第14回天然薬物の開発と応用シンポジウム 講演要旨集) -- (一般講演 天然資源と医薬品開発1)
- Furostanol glycosides from the rhizomes of Helleborus orientalis
- New Steroidal Glycosides from Rhizomes of Clintonia udensis
- Triterpenoids from Rosa multiflora(Natural Medicine Note)
- Chemical Constituents from Dioscorea delicata(Natural Medicine Note)
- Triterpene Saponins from the Leaves of Sesbania sesban(Natural Medicine Note)
- Cytotoxic Alkaloids from the Barks of Ochrosia elliptica(Natural Medicine Note)
- Two New Steroidal Glycosides from Tacca chantrieri
- Five New Triterpene Glycosides from Centella asiatica
- Polymethoxylated Flavonoids from the Peels of Citrus depressa(Natural Medicine Note)
- Steroidal Saponins from the Bulbs of Allium ampeloprasum
- Steroidal Saponins from the Bulbs of Allium aflatunense
- Honeybee Royal Jelly and Nobiletin Stimulate CRE-Mediated Transcription in ERK-Independent and -Dependent Fashions, Respectively, in PC12D Cells