Sesquiterpenoids and Flavonoids from the Aerial Parts of Tithonia diversifolia and Their Cytotoxic Activity
スポンサーリンク
概要
- 論文の詳細を見る
Cytotoxicity-guided fractionation of the 80% EtOH extract of Tithonia diversifolia has resulted in the isolation of twelve sesquiterpenoids (1-12), including three new ones (4, 10, 12), and three known flavonoids (13-15). The structures of the new compounds were determined by analysis of their spectroscopic data. The isolated compounds showed cytotoxic activity against HL-60 leukemia cells with IC_<50> values ranging from 0.13 to 13.0μM, when etoposide used as a positive control gave an IC_<50> value of 0.43μM. The cancer growth inhibitory property of 9, the main cytotoxic compound in T. diversifolia, was examined using a disease-oriented panel composed of 39 human cancer cell lines in the Japanese Foundation for Cancer Research.
- 公益社団法人日本薬学会の論文
- 2007-08-01
著者
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三巻 祥浩
東京薬大・薬・漢方資源応用
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YAMORI Takao
Division of Molecular Pharmacology, Cancer Chemotherapy Center, Japanese Foundation for Cancer Resea
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Yamori Takao
東京薬科大学 薬学部漢方資源応用学
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三巻 祥浩
School Of Pharmacy Tokyo Univ. Of Pharmacy And Life Sciences
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Yamori Takao
Division Of Experimental Chemotherapy Cancer Chemotherapy Center Japanese Foundation For Cancer
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Kuroda M
Laboratory Of Medicinal Pharmacognosy Tokyo University Of Pharmacy And Life Sciences School Of Pharm
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Kuroda Minpei
Laboratory Of Medicinal Pharmacognosy Tokyo University Of Pharmacy And Life Science School Of Pharma
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黒田 明平
東京薬大薬
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Yokosuka Akihito
Lab. Of Medicinal Pharmacognosy School Of Pharmacy Tokyo Univ. Of Pharmacy And Life Sciences
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MIMAKI Yoshihiro
Laboratory of Medicinal Plant Science, School of Pharmacy, Tokyo University of Pharmacy and Life Sci
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Jitsuno Maki
Laboratory of Medicinal Pharmacognosy, School of Pharmacy, Tokyo University of Pharmacy and Life Sci
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Yokosuka Akihito
Laboratory of Medicinal Pharmacognosy, School of Pharmacy, Tokyo University of Pharmacy and Life Sci
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Mimaki Y
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Mimaki Yoshihiro
Laboratory Of Medical Plant Science Tokyo University Of Pharmacy And Life Science
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Kobayashi Ryosuke
Laboratory Of Medicinal Pharmacognosy Tokyo University Of Pharmacy And Life Sciences
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Kuroda M
東京薬大
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KANDO Hiroaki
Hiro International Co., Ltd.
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NOSAKA Kosuke
Hiro International Co., Ltd.
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ISHII Hiroyasu
Hiro International Co., Ltd.
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Mimaki Yoshihiro
Lab. Of Medicinal Pharmacognosy School Of Pharmacy Tokyo Univ. Of Pharmacy And Life Sciences
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Mimaki Yoshihiro
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Kando Hiroaki
Hiro International Co. Ltd.
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Nosaka Kosuke
Hiro International Co. Ltd.
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Ishii Hiroyasu
Hiro International Co. Ltd.
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Mimaki Yoshihiro
School Of Pharmacy Tokyo Univ. Of Pharmacy And Life Sciences
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Kuroda Minpei
Laboratory Of Medicinal Pharmacognosy Tokyo University Of Pharmacy And Life Science School Of Pharma
-
Yamori Takao
Division Of Molecular Pharmacology Cancer Chemotherapy Center Japanese Foundation For Cancer Researc
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Yokosuka Akihito
Laboratory Of Medicinal Pharmacognosy School Of Pharmacy Tokyo University Of Pharmacy And Life Scien
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Yokosuka Akihito
Laboratory Of Medicinal Pharmacognosy School Of Pharmacy Tokyo University Of Pharmacy And Life Scien
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Jitsuno Maki
Lab. Of Medicinal Pharmacognosy School Of Pharmacy Tokyo Univ. Of Pharmacy And Life Sciences
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