125(P-84) 和漢薬「蒟蒻薯(Tacca chantrieriの根茎)」の化学成分と細胞毒性活性(ポスター発表の部)

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The genus Tacca (Taccaceae) with about 10 species is mainly distributed in tropical region of Asia, The Pacific Islands, and Australia. Tacca chantrieri Andre is a perennial plant that grows in southeastern China. Its rhizomes have been used in Chinese folk medicine for the treatment of gasteric ulcer, enterists, and hepatitis. Chemical examination of the rhizomes of T. chantrieri has led to the isolation of a total of 41 compounds, which are classified into diarylheptanoides (1 and 2), diarylheptanoide glucosides (3-9), ergostane glucosides (10-21), withanolide glucosides (22 and 23), spirostan glycosides (24-28), furostan glycosides (29-32), pseudofurostan glycosides (33-37), pregnane glycosides (38-40), and a cholestane glycoside (41). Their structures were determined on the basis of extensive spectroscopic studies, including the ^1H-^1H COSY, selective-TOCSY, HSQC-TOCSY, HMQC, and HMBC spectral data, and by hydrolytic cleavage followed by chromatographic and spectroscopic analysis, and further chemical transformations. The isolated compounds were evaluated for their cytotoxic activity against HL-60 human promyelocytic leukemia cells. Diarylheptanoides (1 and 2), diarylheptanoide glucosides (3, 4, 6, and 7), and spirostan glycosides (24 and 25) showed cytotoxic activity (IC_<50> 1.8-6.4μg/mL). Subsequent evaluation of 2 and 25 in the Jpn. Fdn. for Cancer Res. 38 cell line assay showed that the mean concentration required to achieve GI_<50> levels against the panel of cells were 87μM and 1.8μM respectively. Although 2 and 25 exhibited no significant differential cellar sensitivity, some cell lines such as colon cancer HCT-116 (GI_<50> 25μM), ovarian cancer OVCAR-3 (GI_<50> 36μM), OVCAR-4 (GI_<50> 39μM), and stomach MKN-7 (GI_<50> 34μM) were relatively sensitive to 2.
天然有機化合物討論会の論文
2004-10-01

125(P-84) 和漢薬「蒟蒻薯(Tacca chantrieriの根茎)」の化学成分と細胞毒性活性(ポスター発表の部)

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