Norlanostane and Lanostane Glycosides from the Bulbs of Chionodoxa luciliae and Their Cytotoxic Activity
スポンサーリンク
概要
- 論文の詳細を見る
Ten lanostane glycosides (1-10), including two new norlanostane glycosides (2 and 7) and a new lanostane glycoside with a spirolactone ring system (9), were isolated from the fresh bulbs of Chionodoxa luciliae (Liliaceae). The structures of the new compounds were determined on the basis of extensive spectroscopic analysis and the results of hydrolytic cleavage to be (23S)-3β-[(O-β-D-apiofuranosyl-(1⟶2)-O-[β-D-glucopyranosyl-(1⟶3)]-O-β-D-glucopyranosyl-(1⟶2)-α-L-arabinopyranosyl-(1⟶6)-β-D-glucopyranosyl)oxy]-17α,23-epoxy-28,29-dihydroxy-27-norlanost-8-en-24-one (2), (23S)-17α,23-epoxy-29-hydroxy-3β-[(O-α-L-rhamnopyranosyl-(1⟶2)-O-[O-β-D-glucopyranosyl-(1⟶2)-β-D-glucopyranosyl-(1⟶3)]-O-β-D-glucopyranosyl-(1⟶2)-α-L-arabinopyranosyl-(1⟶6)-β-D-glucopyranosyl)oxy]-27-norlanost-8-ene-15,24-dione (7), and (23S,25R)-17α,23-epoxy-29-hydroxy-3β-[(O-α-L-rhamnopyranosyl-(1⟶2)-O-[β-D-glucopyranosyl-(1⟶3)]-O-β-D-glucopyranosyl-(1⟶2)-α-L-arabinopyranosyl-(1⟶6)-β-D-glucopyranosyl)oxy]lanost-8-en-23,26-olide (9), respectively. The cytotoxic activity of the isolated compounds against HSC-2 human oral squamous cell carcinoma cells are also reported.
- 公益社団法人日本薬学会の論文
- 2003-01-01
著者
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三巻 祥浩
東京薬大・薬・漢方資源応用
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Sakagami Hiroshi
Department of Health and Nutrition Sciences,Tokyo Seiei College
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Sakagami H
Dep. Of Dental Pharmacology Meikai Univ. School Of Dentistry
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Sakagami H
Dep. Of Diagnostic And Therapeutic Sciences School Of Dentistry Meikai Univ.
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三巻 祥浩
School Of Pharmacy Tokyo Univ. Of Pharmacy And Life Sciences
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Kuroda M
Laboratory Of Medicinal Pharmacognosy Tokyo University Of Pharmacy And Life Sciences School Of Pharm
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Kuroda Minpei
Laboratory Of Medicinal Pharmacognosy Tokyo University Of Pharmacy And Life Science School Of Pharma
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黒田 明平
東京薬大薬
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MIMAKI Yoshihiro
Laboratory of Medicinal Plant Science, School of Pharmacy, Tokyo University of Pharmacy and Life Sci
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SASHIDA Yutaka
Laboratory of Medicinal Plant Science, School of Pharmacy, Tokyo University of Pharmacy and Life Sci
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ORI Kazutomo
Laboratory of Medicinal Plant Science, School of Pharmacy Tokyo University of Pharmacy and Life Scie
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Ori Kazutomo
Laboratory Of Medicinal Plant Science School Of Pharmacy Tokyo University Of Pharmacy And Life Scien
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Sakagami Hiroshi
Department Of Dental Pharmacology Meikai University School Of Dentistry
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Mimaki Y
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Mimaki Yoshihiro
Laboratory Of Medical Plant Science Tokyo University Of Pharmacy And Life Science
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Kuroda M
東京薬大
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Mimaki Yoshihiro
Lab. Of Medicinal Pharmacognosy School Of Pharmacy Tokyo Univ. Of Pharmacy And Life Sciences
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Sashida Y
Laboratory Of Medicinal Plant Science School Of Pharmacy Tokyo University Of Pharmacy And Life Scien
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Sashida Yutaka
Laboratory Of Medical Plant Science Tokyo University Of Pharmacy And Life Science
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Sashida Yutaka
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Mimaki Yoshihiro
School Of Pharmacy Tokyo Univ. Of Pharmacy And Life Sciences
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Kuroda Minpei
Laboratory Of Medicinal Pharmacognosy Tokyo University Of Pharmacy And Life Science School Of Pharma
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Sakagami Hiroshi
Department Of Biochemical Pharmacology Tokyo Metropolitan Institute Of Gerontology
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Mimaki Yoshihiko
Laboratory of Medicinal Plant Science, School of Pharmacy Tokyo University of Pharmacy and Life Science
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Sashida Yutaka
Laboratory of Medicinal Plant Science, School of Pharmacy, Tokyo University of Pharmacy and Life Science
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