Polyphenols from Eriobotrya japonica and Their Cytotoxicity against Human Oral Tumor Cell Lines
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概要
- 論文の詳細を見る
Three new flavonoid glycosides, togethr with 15 known flavonoids, have been isolated from the leaves of Eriobotrya japonica, and characterized as (2S)- and (2R)-naringenin 8-C-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranosides, and cinchonain Id 7-O-β-D-glucopyranoside, respectively, based on spectral analyses including two dimensional (2D) NMR techniques. Higher proanthocyanidin fraction in the water-soluble portion of the extract was characterized as a procyanidin oligomer mixture mainly composed of undecameric procyanidin. These polyphenols have also been assessed for cytotoxic activity against two human oral tumor (human squamous cell carcinoma and human salivary gland tumor) cell lines. Selective cytotoxicity of the procyanidin oligomer between tumor and normal gingival fibroblast cells, and its possible mechanism, were also described.
- 公益社団法人日本薬学会の論文
- 2000-05-01
著者
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伊東 秀之
岡山大学大学院医歯薬学総合研究科創薬生命科学専攻
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吉田 隆志
Department Of Pharmacognosy College Of Pharmaceutical Sciences Matsuyama University
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KUSAMA Kaoru
Department of Pathology, Nihon University School of Dentistry
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YOSHIDA Takashi
Faculty of Pharmaceutical Sciences, Matsuyama University
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Ito Hideyuki
Faculty of Pharmaceutical Sciences, Okayama University
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Hatano Tsutomu
Faculty of Pharmaceutical Sciences, Okayama University
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Hatano Tsutomu
エジプト
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Hatano Tsutomu
Division Of Pharmaceutical Sciences Okayama University Graduate School Of Medicine Dentistry And Pha
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Sakagami Hiroshi
Department of Health and Nutrition Sciences,Tokyo Seiei College
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Sakagami H
Dep. Of Diagnostic And Therapeutic Sciences School Of Dentistry Meikai Univ.
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土屋 博紀
Asahi Univ. School Of Dentistry Gifu Jpn
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土屋 博紀
朝日大学歯学部口腔細菌学講座
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Kusama Kaoru
Department Of Dental Pharmacology Meikai University School Of Dentistry
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SHIMURA Susumu
Central Laboratory Lotte Co., Ltd.
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Satoh Kazue
Analysis Center, School of Pharmaceutical Sciences,Showa University
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ITOH YOSHIO
Central Laboratory, Lotte Co. Ltd.,
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Satoh Kazue
Analysis Center School Of Pharmaceutical Sciences Showa University
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KOBAYASHI Eri
Faculty of Pharmaceutical Sciences, Kiniki University
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Sakagami Hiroshi
Department Of Dental Pharmacology Meikai University School Of Dentistry
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TAKAMATSU Yoshie
Faculty of Pharmaceutical Sciences, Okayama University
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LI Shu-Hua
Faculty of Pharmaceutical Sciences, Okayama University
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SUGITA Daigo
Central Research Institute of Lotte Co. Ltd.,
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Hatano Tsutomu
Faculty Of Pharmaceutical Sciences Okayama University
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Shimura Susumu
Central Laboratory Lotte Co. Ltd.
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Shimura Susumu
Central Research Institute Of Lotte Co. Ltd.
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Kobayashi Eri
Faculty Of Pharmaceutical Sciences Kiniki University
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Kobayashi Eri
Faculty Of Pharmaceutical Sciences Okayama University
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Yoshida Takashi
Faculty Of Agriculture Kyusyu University
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Ito Hideyuki
Faculty Of Pharmaceutical Sciences Okayama University
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Ito Hideyuki
Department Of Pharmacognosy Pharmaceutical Sciences Okayama University Graduate School Of Medicine D
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Li Shu-hua
Faculty Of Pharmaceutical Sciences Okayama University
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Shinomiya Kazuaki
Dep. Of Pharmacology Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okayama Univ.
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Sugita Daigo
Central Research Institute Of Lotte Co. Ltd.
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Sakagami Hiroshi
Department Of Biochemical Pharmacology Tokyo Metropolitan Institute Of Gerontology
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Itoh Yoshio
Central Research Institute Of Lotte Co. Ltd.
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Ito Hideyuki
Faculty Of Applied Biological Sciences Gifu University
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Yoshida Takashi
Faculty Of Agriculture And Life Science Hirosaki University
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