P-17 阿仙薬に含まれるポリフェノール成分(ポスター発表の部)
スポンサーリンク
概要
- 論文の詳細を見る
Gambir, Uncaria gambir extract, has been used as an astringent medicine in Asian countries. Investigation on the polyphenolic constituents in gambir led to the isolation of three known proanthocyanidin dimmers, procyanidin B1 (3). procyanidin B3 (4) and gambiriin C (5), and five chalcane-tlavan dimmers, gambiriin A1 (6), A2 (7), B1 (8) B2 (9) and A3 (15), in addition to (+)-catechin (1), (+)-epicatechin (2). Present study revealed that the previously reported structures of gambiriin A1, A2, B1 and B2 should be revised to 6, 7, 8 and 9, respectively. A new B-type procyanidin, catechin-(4α→8)-ent-epicatechin (10), and new chalcane-flavan dimmers, gambirflavan D1 (11), D2 (12), D3 (13), D4 (14) were also isolated and their structures were established. A new chlcane-flavan dimer. gambirflavan DH-1 (17) was isolated from the product mixture obtained upon heating of 1. together with compounds 2, 6-9 and 11-15. Since the chalcane-flavan dimers were formed on heating reaction of 1. they might be formed during the manufacturing process of gambir extracts. while proantocyanidin dimers. 3, 4 and 5, are regarded to be the genuine constituents of Uncaria gambir leaves. The analyses of gambir product indicated that oligomeric and polymeric compounds were also contained, and they increased by longer treatment in the manufacturing process. These higher molecular plolyphenolic constituents may also affect the pharmaceutical properties of gambir. The structural finding obtained in this study might be useful for the investigation of such higher-molecular polyphenolics.
- 天然有機化合物討論会の論文
- 2006-09-15
著者
-
柴田 高
大幸薬品株式会社
-
吉田 隆志
Department Of Pharmacognosy College Of Pharmaceutical Sciences Matsuyama University
-
波多野 力
Department Of Pharmacognosy Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okayam
-
柴田 高
大幸薬品(株)
-
土居 功一
大幸薬品株式会社
-
米田 裕治
大幸薬品株式会社
-
田部 昌弘
大幸薬品株式会社
-
土居 功一
大幸薬品(株)
-
米田 裕治
大幸薬品(株)
-
田部 昌弘
大幸薬品(株)
-
谷口 抄子
岡山大院医歯薬
-
黒田 佳代
岡山大院医歯薬
-
稲田 和敏
岡山大院医歯薬
-
吉田 隆志
岡山大院医歯薬
-
波多野 力
岡山大院医歯薬
-
Hatano Tsutomu
エジプト
-
Hatano Tsutomu
Division Of Pharmaceutical Sciences Okayama University Graduate School Of Medicine Dentistry And Pha
-
吉田 哲也
広島大学医学部
-
柴田 高
大幸薬品
-
黒田 佳代
岡山大学大学院医歯薬学総合研究科
-
Hatano Tsutomu
Department Of Pharmacognosy Okayama University Graduate School Of Medicine Dentistry And Pharmaceuti
-
Yoshida T
Department Of Pharmacognosy College Of Pharmaceutical Sciences Matsuyama University
-
Takahashi Y
Research And Development Headquaters Hokuriku Seivaku Co. Ltd.
-
Yoshida T
Hokuriku Seiyaku Co. Ltd. Fukui Jpn
-
Yoshida T
Department Of Microbiology Hiroshima University School Of Medicine
-
谷口 抄子
岡山大学大学院医歯薬学総合研究科
-
Yoshida T
College Of Pharmaceutical Sciences Matsuyama University
-
吉田 隆志
College Of Pharmaceutical Sciences Matsuyama University
-
稲田 和敏
岡山大学大学院医歯薬学総合研究科
-
Yoshida Takuji
Showa Pharmaceutical University
関連論文
- 9 二酸化塩素スプレーの蚊に対する忌避作用について(第61回日本衛生動物学会東日本支部大会講演要旨)
- スギヒラタケに含まれる特徴的な長鎖脂肪酸について
- 66 ツバキおよび近縁植物の抗HIV作用を有するタンニン(ポスター発表の部)
- Tannins and Related Polyphenols of Euphorbiaceous Plants. IX. Hydrolyzable Tannins with ^1C_4 Glucose Core form Phyllanthus flexuosus MUELL. ARG.
- Hydrolyzable Tannins as Antioxidants in the Leaf Extract of Eucalyptus globulus Possessing Tyrosinase and Hyaluronidase Inhibitory Activities
- 29 大環状構造を有する抗腫瘍性加水分解性タンニンオリゴマー(ポスター発表の部)
- Woodfordin C, a Macro-ring Hydrolyzable Tannin Dimer with Antitumor Activity, and Accompanying Dimers from Woodfordia fruticosa Flowers
- CAMELLIIN B AND NOBOTANIN I, MACROCYCLIC ELLAGITANNIN DIMERS AND RELATED DIMERS, AND THEIR ANTITUMOR ACTIVITY
- Relationship between the Structures and the Antitumor Activities of Tannins(Pharmacological)
- 新型インフルエンザウイルスの対策 その1 : 空間消毒方法
- B-15 阿仙薬のポリフェノール成分による品質評価(薬物代謝・天然物化学,一般演題口演,第24回和漢医薬学会大会 和漢薬の複雑さ-経験知と科学知-)
- 阿仙薬のポリフェノール性成分による品質評価
- Antimicrobial Activity of Oleanolic Acid from Salvia officinalis and Related Compounds on Vancomycin-Resistant Enterococci (VRE)(Microbiology)
- Cowaniin, a C-Glucosidic Ellagitannin Dimer Linked through Catechin from Cowania mexicana
- Potentiation of Antimicrobial Activity of Aminoglycosides by Carnosol from Salvia officinalis(Microbiology)
- Revised Structures of Gambiriins A1, A2, B1, and B2, Chalcane-Flavan Dimers from Gambir (Uncaria gambir Extract)
- Effects of Chlorogenic Acid and Its Metabolites on Spontaneous Locomotor Activity in Mice
- P-17 阿仙薬に含まれるポリフェノール成分(ポスター発表の部)
- Conjugated Ketonic Fatty Acids from Pleurocybella porrigens
- P-236 CONJUGATED LONG-CHAIN FATTY ACIDS OF PLEUROCYBELLA PORRIGENS
- P-172 ANTIFUNGAL CONSTITUENTS FROM SANTALUM ALBUM OF INDIAN ORIGIN
- Urinary Excretion of Anthocyanins in Humans after Cranberry Juice Ingestion
- Polyphenolic Constituent Structures of Zanthoxylum piperitum Fruit and the Antibacterial Effects of Its Polymeric Procyanidin on Methicillin-Resistant Staphylococcus aureus
- Synergistic Effect of [10]-Gingerol and Aminoglycosides against Vancomycin-Resistant Enterococci (VRE)(Microbiology)
- Water-Soluble Complexes Formed by Natural Polyphenols and Bovine Serum Albumin : Evidence from Gel Electrophoresis
- Interaction of the Aryl Hydrocarbon Receptor with Several Constituents from Spinach and Komatsuna Extracts Determined Using in Vitro Bioassay
- Cypellogins A, B and C, Acylated Flavonol Glycosides from Eucalyptus cypellocarpa
- Remarkable Synergies between Baicalein and Tetracycline, and Baicalein and β-Lactams against Methicillin-Resistant Staphylococcus aureus
- Two New Analogues of Trijugin-Type Limonoids from the Leaves of Sandoricum koetjape
- Chemical Constituents of Artemisia herba-alba Asso
- 天然ナノ分子タンニン : その構造と機能
- Antibacterial Activity of Hydrolyzable Tannins Derived from Medicinal Plants against Helicobacter pylori
- K-083(30) 茶葉ポリフェノールの血清アルブミンとの複合体形成
- メチシリン耐性黄色ブドウ球菌(MRSA)に対する山椒中の作用物質
- ビワ葉の抗腫瘍性成分
- Hydrolysable Tannin Production in Oenothera tetraptera Shoot Tissue Culture
- 天然由来抗MRSA物質の探索
- E-5 大棗のポリフェノール成分とそのメチシリン耐性黄色ブドウ球菌に対する抗生物質耐性抑制作用
- Proanthocyanidins and Related Compounds:Antileishmanial Activity and Modulatory Effects on Nitric Oxide and Tumor Necrosis Factor-α-Release in the Murine Macrophage-Like Cell Line RAW 264.7
- P-87 山椒のMRSAに対する抗菌作用成分
- Phenolic Constituents of Licorice. VIII. Structures of Glicophenone and Glicoisoflavanone, and Effects of Licorice Phenolics on Methicillin-Resistant Staphylococcus aureus
- Convenient TLC-based Identification Test for the Crude Drug "Pogostemoni Herba"
- 木クレオソート製剤の史的変遷
- Flavonol Glycosides in Leaves of Two Diospyros Species
- サイクレン亜鉛錯体ダイマーの抗ウイルス(HIV)活性に対するダイマー化と錯形成の寄与(発表論文抄録(1996))
- Inhibition of Human Immunodeficiency Virus Proliferation by Macrocyclic Polyamines and Their Metal Complexes
- Enzymatic Sulfation of isoamyl Gallate and (-)-Epigallocatechin Gallate by Bacterial Arylsulfotransferase
- 125 低濃度二酸化塩素ガスのアレルゲン不活化剤としての検討(アレルゲン,抗原2,一般演題(デジタルポスター),第57回日本アレルギー学会秋季学術大会)
- Structures of Alnusiin and Bicornin, New Hydrolyzable Tannins Having a Monolactonized Tergalloyl Group
- Studies on Inhibition Mechanism of Autoxidation by Tannins and Flavonoids. V. Radical-Scavenging Effects of Tannins and Related Polyphenols on 1,1-Diphenyl-2-picrylhydrazyl Radical
- Spectral and Chromatographic Analyses of Tannins. I. ^C Nuclear Magnetic Resonance Spectra of Hydrolyzable Tannins
- 21 加水分解性タンニンオリゴマーおよび関連タンニンのNMRとMSスペクトル解析
- P-448 STRUCTURES OF STILBENE OLIGOMERS IN DIPTEROCARPACEAEOUS PLANTS
- New resveratrol oligomers in the stem bark of Vatica pauciflora
- Negamycin Restores Dystrophin Expression in Skeletal and Cardiac Muscles of mdx Mice
- Six New Heterocyclic Stilbene Oligomers from Stem Bark of Shorea hemsleyana.
- Five New Oligostilbenes with One or Two Dihydrofurans form the Stem Bark of Vatica rassak.
- A Novel Bridged Stilbenoid Trimer and Four Highly Condensed Stilbenoid Oligomers in Vatica rassak.
- A New Resveratrol Octamaer, Vateriaphonol A, in Vateria indica.
- Vaticanol D, a Novel Resveratrol Hexmer Isolated from Vatica rassak.
- Migrastatin, a Novel 14-Membered Lactone from Streptomyces sp. MK929-43F1
- Dimeric Chalcone Derivatives from Mallotus philippensis.
- Inhibition of Angiogenesis by a New Isocoumarin, NM-3
- Lactonamycin, a New Antimicrobial Antibiotic Produced by Streptomyces rishiriensis MJ773-88K4 II. Structure Determination
- Lactonamycin, a New Antimicrobial Antibiotic Produced by Streptomyces rishiriensis MJ773-88K4 I. Taxonomy, Fermentation, Isolation, Physico-chemical properties and Biological Activities
- Activation of the Aryl Hydrocarbon Receptor by Some Vegetable Constituents Determined Using in Vitro Reporter Gene Assay
- Preliminary Screening of the lnhibitory Effect of Food Extracts on Activation of the Aryl Hydrocarbon Receptor Induced by 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin
- Generation of New Benanomicin Analogues by Biotransformation Using Escherchia coli Expressing Actinomycete Cytochrome P450
- 超臨界流体抽出の生薬, 植物成分への応用(第2報)クマリン, リグナン及びプレニルフラボノイドについて
- Ellagitannin Monomers and Oligomers from Euphorbia prostrata AIT. and Oligomers from Loropetalum chinense OLIV.
- EUPHORBIN E, A HYDROLYZABLE TANNIN DIMER OF HIGHLY OXIDIZED STRUCTURE, FROM EUPHORBIA HITRA
- Tannins and Related Polyphenols of Euphorbiaceous Plants. V. : Euphorbin C, an Equilibrated Dimeric Dehydroellagitannin Having a New Tetrameric Galloyl Group
- 79(P2-9) トウダイグサ科植物の加水分解性タンニンオリゴマー(ポスター発表の部)
- Aromatic Constituents from the Heartwood of Santalum album L.
- Synthesis of Sulfated Deoxy-Ribofuranans Having Selective Anti-AIDS Virus Activity by Ring-Opening Copolymerization of 1,4-Anhydro Ribose Derivatives
- STRUCTURES AND ACTIVITIES OF TANNINS IN CRUDE DRUGS (4) : EFFECTS ON PHAGOCYTES AND VIRUSES
- Novel Assay System Favorable for the Study of Cell-to-Cell Transmission of HIV-1 and Its Application to the Evaluation of Anti-HIV Drugs
- Tannins and Related Polyphenols of Theaceous Plants. VIII. Camelliatannins C and E, New Complex Tannins from Camellia japonica Leaves
- Tannins and Related Polyphenols of Melastomataceous Plants. VII. Nobotanins J and K, Trimeric and Tetrameric Hydrolyzable Tanins from Heterocentron roseum
- Tannins and Related Polyphenols of Melastomataceous Plants. III. Nobotanins G, H and I, Dimeric Hydrolyzable Tannins from Heterocentron roseum
- Tannins and Related Polyphenols of Melastomataceous Plants. II. Nobotanins B, C and E, Hydrolyzable Tannin Dimer and Trimers from Tibouchina semidecandra COGN.
- Tannins and Related Polyphenols of Melastomataceous Plants. I. Hydrolyzable Tannins from Tibouchina semidecandra COGN.
- ^13C Nuclear Magnetic Resonance Spectra of Hydrolyzable Tannins. III. : Tannins Having ^1C_4 Glucose and C-Glucosidic Linkage
- Dioxin Concentrations in Commercial Health Tea Materials in Japan
- タンニンと共存物質との相互作用の効果(第8報)天然色素の変色防止効果
- 82 新種大環状加水分解性タンニンオリゴマーの構造 : 36員環構造のタンニンおよび関連化合物(ポスター発表の部)
- Tannins and Related Polyphenols of Lythraceous Plants. III. Hydrolyzable Tannin Oligomers with Macrocyclic Structures, and Accompanying Tannins from Woodfordia fruticosa KURZ
- Tannins and Related Polyphenols of Theaceous Plants. IV. Monomeric and Dimeric Hydrolyzable Tannins Having a Dilactonized Valoneoyl Group from Schima wallichii KORTH.
- 52 加水分解性タンニンオリゴマーの構成アシル基の配向の系統的解明(口頭発表の部)
- Woodfordin D and Oenothein A, Trimeric Hydrolyzable Tannins of Macro-Ring Structure with Anti-tumor Activity
- Tannins of Theaceous Plants. II. : Camelliins A and B, Two New Dimeric Hydrolyzable Tannins from Flower Buds of Camellia japonica L. and Camellia sasanqua THUNB.
- The Enantioselective Metabolism of p-Cymene in Rabbits
- Polyphenolic compounds isolated from the leaves of Myrtus communis
- DRYOFRAGIN AND ASPIDIN PB, PISCICIDAL COMPONENTS FROM DRYOPTERIS FRAGRANS
- 極低濃度二酸化塩素ガスによる真菌Alternaria alternataの菌糸成長抑制
- Structure-Activity Correlationship and Strain Specificity of Polyoxometalates in Anti-human Immunodeficiency Virus Activity
- 木クレオソートの止瀉作用についての新しい知見
- 木クレオソート製剤の史的変遷(第2報)日本薬局方「木クレオソート」の基原について
- 木クレオソート製剤の史的変遷 (第二報) : 日本薬局方「木クレオソート」の基原について
- 二酸化塩素ガス発生ゲル剤によるネコカリシウイルスの不活化の検討