66 ツバキおよび近縁植物の抗HIV作用を有するタンニン(ポスター発表の部)

概要

論文の詳細を見る
1. Eight new tannins named camelliatannins A-H were isolated from the leaf of Camellia japonica (Theaceae). Structural study revealed that camelliatannins A (10), B (11), C (12), E (14), F (15) and G (16) are complex tannins consisting of a monomeric hydrolyzable tannin and epicatechin, and camelliatannin H (17) is a dimeric hydrolyzable tannin. Camelliatannin D (13) is the first example of complex tannin composed of a dimeric hydrolyzable tannin and epicatechin. Compounds 3 - 9 were also isolated from the leaf. 2. Camelliins A (1) and B (2), dimeric hydrolyzable tannins isolated from the flower of C. japonica, were not found in the leaf, but were isolated from the fruit. Three complex tannins, 10, 13 and 15, and a dimeric hydrolyzable tannin, 17, along with 3, 5, 7, 8, 23 and 24, were also isolated from the fruit. Camelliins A and B were isolated from the flower of C. sasanqua, and were found in the extract of the leaf of C. oleifera. Schimawalin B (25), a dimeric hydrolyzable tannin, and 2, were isolated from the flower of Schima wallichii, a theaceous plant. 3. Among the tannins isolated from the theaceous plants, 2, 10 and 25 inhibited the cytopathic effects induced by human immunodeficiency virus (HIV) (EC_<50>, 4.8-11.8μg/ml). Gemin D (6), a monomeric hydrolyzable tannin contained in several theaceous plants, also showed the anti-HIV activity (EC_<50>, 2.0μg/ml).
天然有機化合物討論会の論文
1992-09-10