20 Trichoderma polysporum代謝産物Trichosporin類の単離と構造

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概要

• 論文の詳細を見る

• Trichosporins are a peptide mixture isolated from culture filtrate of Trichoderma polysporum, which is antagonistic to Leutinus edodes. The pure component, trichosporin (TS)-B-V, has been obtained by preparative HPLC from Trichosporin mixture. This novel peptide has been shown to consit of one acetylated N-terminal residue, 19 amino acids and a phenylalaninol, C-terminal amino alcohol. Moreover, since this peptide contains a high proportion of α-aminoisobutyric acid (Aib) and has a moleculor weight near 2000, it belongs to the class of peptaibophols. Sequence determination (Fig. 8) was based on positive ion FAB mass spectrometry. High-field NMR data with two-demensional NMR assignment techniques were very useful in this study. Furthermore, sequences of the congeners, TS-B-I-a, -III-a, and -III-d were elucidated as shown in Fig. 8.

• 天然有機化合物討論会の論文
• 1986-09-09

著者

• 高石 喜久

  徳島大院薬

• 新宮 徹朗

  神戸学院大薬

• 上里 新一

  Faculty of Pharmaceutical Sciences, Kyoto University

• 上里 新一

  京大薬

• 藤多 哲朗

  摂南大学薬学部

• 飯田 彰

  京大 院 薬

• 藤多 哲朗

  Kyoto Pharmaceutical Univ. Kyoto Jpn

• Takeda Y

  Fac. Of Integrated Arts And Sciences Univ. Of Tokushima

• Takeda Y

  Faculty Of Integrated Arts And Sciences The University Of Tokushima

• 上里 新一

  京都大学薬学部

• 藤多 哲朗

  京大薬

• Iida A

  Graduate School Of Pharmaceutical Sciences Kyoto University

• Iida Akira

  Faculty Of Pharmaceutical Sciences Kyoto University

• 飯田 彰

  京大薬

• 高石 喜久

  徳大薬

• 新宮 徹朗

  神戸学院大学薬学部薬化学講座

• 新宮 徹朗

  神院大・薬

• 新宮 徹朗

  京都大学薬学部

• Shingu K

  School Of Pharmacy Kobe Gakuin University

• 上里 新一

  Department Of Life Science And Biotechnology Faculty Of Chemistry Material And Bioengineering Kansai

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