P-1 中国産イチイ科植物Taxus chinensisの新ジテルペノイド(ポスター発表の部)

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概要

• 論文の詳細を見る

• Taxol, a diterpenoid first isolated from Taxus brevifolia in 1971, invokes a great deal of interest amongst anticancer drugs from plant source due to its promising anticancer activity and unique action mechanism. Extensive chemical and biological investigations on this and related diterpenoids have been carried out worldwide for the purpose of ample and efficient material supply. Search for new taxoids from different kinds of Taxus species might not only lead to a solution of the problem but to a refinement of anticancer activity and formulation. As a part of our program to investigate new axanes of antitumor activity, we have isolated fourteen new diterpenoids from Chinese Taxaceae, Taxus chinensis, together with thirteen known compounds. Their structures were elucidated by spectral means, especially NMR technique. Among fourteen new diterpenoids, ten compounds possess a novel tricyclo 5/7/6-membered ring system, which was unambiguously confirmed by an X-ray analysis. The variable temperature NMR experiments indicated that some of new diterpenoids of this skeleton are more flexible in solution than their taxane counterpart, and exist as a mixture of two conformers at an ambient temperature.

• 天然有機化合物討論会の論文
• 1994-09-20

著者

• 新宮 徹朗

  神戸学院大薬

• 冨士 薫

  Institute For Chemical Research Kyoto University

• 田中 圭

  静岡県大 薬

• 多賀 徹

  京大・薬

• 横井 利夫

  神戸学院大学薬学部薬化学講座

• 横井 利夫

  神戸学院大学薬学部

• 孫 漢董

  中国科学院昆明植物研究所

• 孫 漢董

  中国科学院昆明植物研

• 冨士 薫

  京大・化研

• 新宮 徹朗

  神戸学院大学薬学部薬化学講座

• Shingu K

  Kumamoto Univ. Kumamoto Jpn

• 新宮 徹朗

  神院大・薬

• 新宮 徹朗

  京都大学薬学部

• 李 波

  Kunming Institute Of Botany Academia Sinica

• 李 波

  京大・化研

• 田中 圭

  京大・化研

• Shingu K

  School Of Pharmacy Kobe Gakuin University

• 多賀 徹

  京大・院薬・薬品分子構造

• 田中 圭

  京都大学薬学部

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