Diastereoselectivity in Addition of Methylmagnesium Halide to Benzoylformate of Chiral 1,1'-Binaphthalene-2,2'-diol
スポンサーリンク
概要
- 論文の詳細を見る
The Grignard reactions of mono-benzoylformate ester of 1,1'-binaphthalene-2,2'-diol were examined to investigate the complex-induced proximity effect of the phenolic hydroxyl a+ C-2' under different reaction conditions. This hydroxyl group exerted a significant neighboring group participation in the reaction. The nucleophilic addition reaction proceeded with higher diastereoselectivity than that of a series of sterically similarly sized binaphtyl esters recently reported. The halogen ligand in methyl Grignard reagents plays a crucial role in controlling the degree and sense of diastereoselectivity. A plausible mechanism is also proposed.
- 社団法人日本薬学会の論文
- 1994-04-15
著者
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冨士 薫
Institute For Chemical Research Kyoto University
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谷口 清
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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谷口 清
Institute for Chemical Research, Kyoto University
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安 美子
Institute for Chemical Research, Kyoto University
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水地 真樹
Institute for Chemical Research, Kyoto University
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水地 真樹
Institute For Chemical Research Kyoto University
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安 美子
Institute For Chemical Research Kyoto University
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