Use of 1,1'-Binaphthalene-8,8'-diol as a Chiral Auxiliary for Asymmetric Michael Addition. Application to the Syntheses of Turmeronol A and B

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概要

• 論文の詳細を見る

• Highly diastereoselective Michael addition of lithium diorganocuprates to the half-ester of 1,1'-binaphthalene-8,8'-diol gave β-substituted esters with high enantiomeric excess after methanolysis. The optically active phenolic sesquiterpenes turmeronol A (1) and B(2) have been synthesized using this reaction as a key step.

• 社団法人日本薬学会の論文
• 1999-07-15

著者

• Kinoshita T

  Exploratory Research Laboratoeis Fujisawa Pharmaceutical Co. Ltd.

• 冨士 薫

  Institute For Chemical Research Kyoto University

• FUJI KAORU

  Institute for Chemical Research, Kyoto University

• Asakawa Naoyuki

  Institute For Chemical Research Kyoto University

• TANAKA Kiyoshi

  School of Pharmaceutical Sciences, University of Shizuoka

• NURUZZAMAN Mohammad

  Institute for Chemical Research, Kyoto University

• YOSHIDA Masato

  Institute for Chemical Research, Kyoto University

• YANG Xiao-Shen

  Institute for Chemical Research, Kyoto University

• TSUBAKI Kazunori

  Institute for Chemical Research, Kyoto University

• Tsubaki K

  Institute For Chemical Research Kyoto University

• Yang Xiao-shen

  Institute For Chemical Research Kyoto University

• Fuji Kaoru

  Institute For Chemical Research Kyoto University

• Nuruzzaman M

  Institute For Chemical Research Kyoto University

• Nuruzzaman Mohammad

  Institute For Chemical Research Kyoto University

• 嶽 一彦

  New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

• Tsubaki Kazunori

  Institute For Chemical Research Kyoto University

• Tanaka Kiyoshi

  School Of Pharmaceutical Sciences University Of Shizuoka

• Yoshida Masato

  Institute For Chemical Research Kyoto University

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