Studies on Metabolites of Mycoparasitic Fungi. III. New Sesquiterpene Alcohol from Trichoderma koningii

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概要

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• A new sesquiterpene alcohol, named tricho-acorenol (1), was isolated from the culture broth of Trichoderma koningii OUDEMANS along with methyl benzoate (2), cyclonerodiol (3), cyclo-(L-Pro-L-Leu) (4), 4-hydroxyphenethyl alcohol (5), uracil (7), and a ceramide (6). The ceramide (6) was identified as (2S, 3S, 4R)-2-[(2R)-2-hydroxytetracosanoylamino]-1,3,4-octadecanetriol by the use of ion-spray ionization MS (ISI-MS) and comparison of the optical rotation and the ^1H-NMR data with those of (2S, 3S, 4R)-2-[(2R)-2-hydroxytetracosanoylamino]-1,3,4-hexadecanetriol. The structure of tricho-acorenol was elucidated to be (1S, 4S, 5S, 7R)-1-isopropyl-4,8-dimethyl-spiro-[4.5]dec-8-en-7-ol on the basis of chemical and spectroscopic evidence.

• 公益社団法人日本薬学会の論文
• 1995-06-15

著者

• Kinoshita T

  Exploratory Research Laboratoeis Fujisawa Pharmaceutical Co. Ltd.

• 手塚 康弘

  Research Institute for WAKAN-YAKU (Oriental Medicines), Toyama Medical & Pharmaceutical University

• 菊池 徹

  Research Institute for WAKAN-YAKU (Oriental Medicines) Toyama Medical & Pharmaceutical University

• 黄 慶

  Research Institute for Wakan-Yaku (Oriental Medicines), Toyama Medical and Pharmaceutical University

• 西 荒介

  Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University

• 椿 啓介

  College of Pharmacy, Nihon University

• 菊池 徹

  富山医科薬科大学和漢薬研究所化学応用部門

• 菊池 徹

  Research Institute For Wakan-yaku (oriental Medicines) Toyama Medical And Pharmaceutical University

• 西 荒介

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• 畑中 保丸

  Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University

• 黄 慶

  富山医科薬科大学和漢薬研究所化学応用部門

• 畑中 保丸

  富山医科薬科大学和漢薬研究所化学応用部門

• Hatanaka Yasumaru

  University Of Toyama

• Hatanaka Y

  University Of Toyama

• 菊池 徹

  富山医薬大和漢薬研化学応用

• Tsubaki K

  Institute For Chemical Research Kyoto University

• 椿 啓介

  College Of Pharmacy Nihon University

• 嶽 一彦

  New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.

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