Scopadulcic Acid B, a New Tetracyclic Diterpenoid from Scoparia dulcis L. Its Structure, H^+, K^+-Adenosine Triphosphatase Inhibitory Activity and Pharmacokinetic Behaviour in Rats

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概要

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• The structure of scopadulcic acid B (2,SDB), a major ingredient of the Paraguayan herb "Typycha kuratu" (Scoparia dulcis L.), was elucidated mainly by comparison of its spectral data with that of scopadulcic acid A (1). SDB inhibited both the K^+-dependent adenosine triphosphatase (ATPase) activity of a hog gastric proton pump (H^+, K^+-ATPase) with a value of 20-30μM for IC_<50> and proton transport into grastric vesicles. Pharmacokinetic studies of SDB in rats indicated that plasma SDB concentrations after i.v. injection of the sodium salt of SDB (SDB-Na) were described reasonably well by a two-compartment open model with Michaelis-Menten elimination kinetics. Plasma concentrations after oral administration of SDB-Na or SDB showed a much slower decline than what was expected following the i. v. study. It was suggested that the sustained plasma level of SDB after oral administration of SDB-Na or SDB was accounted for by relatively slow but efficient gastro-intestinal absorption in rats.

• 社団法人日本薬学会の論文
• 1990-10-25

著者

• 森田 直賢

  Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University

• 林 利光

  Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University

• 川崎 勝

  Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University

• 林 利光

  富山医科薬科大学薬学部

• 手塚 康弘

  Research Institute for WAKAN-YAKU (Oriental Medicines), Toyama Medical & Pharmaceutical University

• 菊池 徹

  Research Institute for WAKAN-YAKU (Oriental Medicines) Toyama Medical & Pharmaceutical University

• 岡村 香奈

  Faculty of Pharmaceutical Sciences

• 掛見 正郎

  Faculty of Pharmaceutical Sciences

• 浅野 真司

  Faculty of Pharmaceutical Sciences

• 水谷 基文

  Faculty of Pharmaceutical Sciences

• 竹口 紀晃

  Faculty of Pharmaceutical Sciences

• Shino Akio

  武田薬品工業

• 菊池 徹

  富山医科薬科大学和漢薬研究所化学応用部門

• 菊池 徹

  Research Institute For Wakan-yaku (oriental Medicines) Toyama Medical And Pharmaceutical University

• Kakemi M

  Department Of Biopharmaceutics Osaka University Of Pharmaceutical Science

• 掛見 正郎

  Department Of Biopharmaceutics Osaka University Of Pharmaceutical Science

• 掛見 正郎

  Faculty Of Pharmaceutical Sciences:toyama Medical And Pharmaceutical University

• 森田 直賢

  Department Of Medicinal Resources Faculty Of Pharmaceutical Sciences Toyama Medical & Pharmaceut

• Asano S

  Department Of Pharmacology Faculty Of Pharmaceutical Sciences Osaka University

• Asano Shoichi

  大阪大学 薬 薬理

• Asano Shoichi

  Pharmaceutical Research Division Takeda Chemical Industries Ltd.

• 川崎 勝

  Faculty Of Pharmaceutical Sciences:toyama Medical And Pharmaceutical University

• 林 利光

  富山医科薬科大学薬学部生薬学教室

• 竹口 紀晃

  富山大学大学院医学薬学研究部薬物生理学研究室

• 菊池 徹

  富山医薬大和漢薬研化学応用

• 水谷 基文

  Faculty Of Pharmaceutical Sciences:toyama Medical And Pharmaceutical University

• 林 利光

  Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• 岡村 香奈

  Faculty Of Pharmaceutical Sciences:toyama Medical And Pharmaceutical University

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