Constituents of a Fern, Davallia mariesii MOORE. V.Isolation and Structures of Davallin, a New Tetrameric Proanthocyanidin, and Two New Phenolic Glycosides
スポンサーリンク
概要
- 論文の詳細を見る
A new tetrameric proanthocyanidin named davallin (1) and two new phenolic glycosides, 5-O-β-D-(6-O-vanilloylglucopyranosyl)gentisic acid (6) and 4-O-β-D-(6-O-vanilloylglucopyranosyl)vanillic acid (7), have been isolated from the rhizomes of Davallia mariesii MOORE together with six known compounds, procyanidin B-2 (2) and B-5 (3), epicatechin-(4β→8)-epicatechin-(4β→6)-epicatechin (4), epicatechin-(4β→6)-epicatechin-(4β→8)-epicatechin-(4β→6)-epicatechin (5), protocatechuic acid (8), and 1-naphthol-β-D-glucopyranoside (9). Structures of the three new compounds (1,6,and 7) were determined by means of spectroscopic methods including two-dimensional NMR techniques.Among the compounds obtained, 1 and 2 inhibited protein kinase C with IC_<50> values of 3.5 and 8.6 μM, respectively.
- 社団法人日本薬学会の論文
- 1993-09-15
著者
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手塚 康弘
Research Institute for WAKAN-YAKU (Oriental Medicines), Toyama Medical & Pharmaceutical University
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菊池 徹
Research Institute for WAKAN-YAKU (Oriental Medicines) Toyama Medical & Pharmaceutical University
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山下 浩子
Research Institute For Wakan-yaku (oriental Medicines) Toyama Medical And Pharmaceutical University
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菊池 徹
富山医科薬科大学和漢薬研究所化学応用部門
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菊池 徹
Research Institute For Wakan-yaku (oriental Medicines) Toyama Medical And Pharmaceutical University
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朴 鐘喜
College Of Pharmacy Pusan National University
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崔 承彬
Research Institute For Wakan-yaku (oriental Medicines) Toyama Medical And Pharmaceutical University
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中野 洋文
協和醗酵工業(株)東京研究所
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玉沖 達也
協和醗酵工業(株)東京研究所
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玉沖 達也
Tokyo Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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中野 洋文
Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.,
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中野 洋文
協和発酵・東京研
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中野 洋文
Tokyo Research Laboratories Kyowa-hakko Kogyo Co. Ltd.
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菊池 徹
富山医薬大和漢薬研化学応用
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