Regioselective Monoalkylation of Non-protected Glycopyranosides by the Dibutyltin Oxide Method
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概要
- 論文の詳細を見る
Regioselective monoalkylation of some pento- and hexopyranosides (Me β-L-Ara, Ph α-L-Ara, Me α-D-Xyl, Me β-D-Xyl, Me α-D-Glc, Me β-D-Glc, Me α-D-Gal, Me β-D-Gal, and Me α-D-Man) was examined by using the dibutyltin oxide method without protecting the hydroxyl groups. By this method, alkylation proceeds more or less in the same fashion as reported for acylation (through the formation of cyclic tin intermediates) and selectively activates an equatorial hydroxyl group which has an oxygenated function (OH or OMe) in a cis relationship at an adjacent position, even in the presence of a more reactive primary hydroxyl group. However, in some instances the position of activation is different. Various monoalkyl others thus prepared were identified by analyses of their carbon-13 nuclear magnetic resonance spectra.
- 公益社団法人日本薬学会の論文
- 1985-06-25
著者
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津田 喜典
金沢大学
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津田 喜典
Faculty of Pharmaceutical Sciences, Kanazawa University
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菊池 徹
Research Institute for WAKAN-YAKU (Oriental Medicines) Toyama Medical & Pharmaceutical University
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津田 喜典
金沢大学薬学部
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津田 喜典
Faculty Of Pharmaceutical Sciences Kanazawa University
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菊池 徹
Research Institute For Wakan-yaku (oriental Medicines) Toyama Medical And Pharmaceutical University
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吉本 公浩
金沢大学薬学部
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Haque Mohammed
Research Institute For Wakan-yaku (oriental Medicines) Toyama Medical And Pharmaceutical University
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