90(P04) β-エリスロイジンの合成研究(ポスター発表の部)
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概要
- 論文の詳細を見る
Erythrina Alkaloids are remarkable for their strong curare-like action appeared on oral administration. Total syntheses of those which have an aromatic group at ring D (aromatic Erythrina alkaloids) have been accomplished, but synthesis of so-called non-aromatic Erythrina alkaloids, all of which have an unsaturated lactone ring at ring D instead of an aromatic group, is still elusive. This study is based on a strategy involving the following three steps: 1) construction of the erythrinan skeleton having a furan ring through Diels-Alder reaction of furodioxopyrroline (2) with an activated butadienes, 2) conversion to oxirane carboxylic acid (11) via oxidative fission of the furan ring, 3) construction of the unsaturated δ-lactone by one carbon homologation followed by cyclization. The conversion of the γ-lactone (26) into β-erythroidine (1) is currently under progress. The preliminary experiments with model compounds will also be presented.
- 天然有機化合物討論会の論文
- 1996-09-02
著者
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津田 喜典
金沢大学
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細井 信造
金沢大薬
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津田 喜典
金沢大薬
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水戸 祥子
金沢大薬
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佐野 武弘
昭和薬大
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佐野 武弘
昭和薬科大学
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佐野 武弘
Showa Pharmaceutical Univ. Tokyo Jpn
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